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Mechanisms of Autoimmunity: More Reasons Gut Health and Toxin Reduction are Crucial
275 Plays2 years ago
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The above 3 courses cover topics such as gut dysfunction and infections, clostridia bacteria, Candida, oxalates, methylation, excitotoxicity, zinc / copper imbalance, going gluten-free and how to do it well, heavy metals and chemical toxicity, probiotic supplementation, mitochondrial dysfunction, immune system dysregulation, neuroinflammation, and much much more. I even show you how to select high-quality supplements and avoid the junk and hype - with real examples and analysis of ingredients on screen...
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Transcript
Introduction to Autoimmunity
00:00:01
Speaker
Hi, Christian Jordonov here. Thanks for stopping by. Today I want to have a brief discussion on some of the mechanisms through which autoimmunity can develop in the body.
The Role of Gut Health and Toxic Exposure
00:00:19
Speaker
And this will underscore why
00:00:22
Speaker
Gut health and gut lining integrity is so crucial and also why toxic exposure reduction through diet, air, water and products that you use is also super crucial
00:00:44
Speaker
in order to preserve health or get back to a state of good health. Whether that's for your children or for yourself, these terms or these concepts will cover
00:00:58
Speaker
really apply to children and of course anybody, right?
Autoimmune Mechanisms in Children and Adults
00:01:06
Speaker
So I'll be just going over some stuff from a chapter in my book, Autism Wellbeing Plan, How to Get Your Child Healthy.
00:01:16
Speaker
Check out the book if you haven't if you are interested in the auto autism aspect and children's health aspect but for adults again the mechanisms are basically the exact same except when you have an adult.
00:01:34
Speaker
You've already gone past the neurodevelopmental stage, so autoimmune reactions are going to have different manifestations in the body. So it affects children, it affects adults.
Understanding the Immune System
00:01:52
Speaker
So a couple of things we want to get out of the way, just to give you a primer on
00:01:56
Speaker
the terms that relate to the discussion relating to the immune system that will cover. So obviously, you know what the immune system is? It protects you from pathogens, foreign invaders. It monitors the blood for anything that it doesn't recognize. And if it doesn't recognize something, it will create
00:02:18
Speaker
that's an antigen, some type of could be a piece of undigested food, it could be a chemical, heavy metal, an infectious organism. So that is the antigen that the immune system will quote-unquote label or tag as a foreign invader, something that must be neutralized, excreted and so on.
00:02:46
Speaker
When it recognizes something as an antigen, the immune system will create the antibody. Now the antibodies, they're also known as immunoglobulins. So if you see like a food sensitivity or allergy test, they talk about IgG antibodies or IgE antibodies, right?
00:03:12
Speaker
So you've got your antigen, your antibody, right? Now the antibodies are created by the, there's what we can call the adaptive arm of the immune system. It's also called the humoral immune response. And you also have the cell mediated or innate immune system, right? So there's different mechanisms, but when it comes to
00:03:39
Speaker
antibody creation, antigens and stuff like that. We use the adaptive arm. So this is like the immune system that gets trained.
00:03:47
Speaker
from basically day one of life. As we're exposed to various different chemicals, particles, bacteria, et cetera, the immune system starts making antibodies. So let's say the first time you have a lot of these childhood illnesses, whatever, measles or other stuff, you have it once generally.
00:04:14
Speaker
You your body fights it for for a few days or whatever you mount that antibody response and now you've got your Antibodies for life usually and then you should not you should not probably in the future You know get sick from that thing because you have the antibodies you have your little soldiers that are ready to attack it right and neutralize that particular Whether it's a whatever illness it is right now
When the Immune System Goes Wrong
00:04:44
Speaker
Now, here's where things can go wrong. So we have antigens and antibodies.
00:04:55
Speaker
When things get dysregulated in the immune system, that's where autoantibodies start getting created. So this is one of the main mechanisms of autoimmune disorders. And basically what an autoantibody is, it's an antibody
00:05:18
Speaker
created that targets part of your cell or your child's cell a protein or other tissues of the body that could be a brain cell like a neuron or something in the nervous system it could be the gut like in celiac disease any number of tissues can be attacked it could be the cartilage and the joints and
00:05:45
Speaker
This is where we can classify or the medical system classifies different types of autoimmune diseases and disorders depending on what gets attacked, right? So the question then is, why does the immune system start doing this? Why does it become dysregulated? And this is a quote from my book.
Factors Overstimulating the Immune System
00:06:10
Speaker
The question remains,
00:06:13
Speaker
This is from a paper that I cite in my book. Quote, the question remains, what is causing the chronic immune activation of the brain? This is related to autism.
00:06:30
Speaker
We believe that there is compelling evidence that excessive systemic immune stimulation through a combination of numerous and closely spaced vaccinations, immune and excitotoxic effects of mercury additive thimerosal, systemic infections, food allergies, candida infections and genetic factors all play a part."
00:06:57
Speaker
So a number of internal or external stressors can perturb the immune system, both again of a growing child or an adult, right? So infections, allergies, toxins in food and medications and so on, right? So it comes down to genetic variation, what you or your child is susceptible to, right? Someone might be more
00:07:23
Speaker
It could be more of a brain thing. It could be more of a joints thing. It all depends on the predispositions we have. And then, of course, the toxic onslaught that dysregulates the immune system. So it all starts really with some type of immune system dysfunction. And the
00:07:47
Speaker
When it comes to children, the maternal environment, so the health of the mother, whether she has autoimmune conditions to begin with like diabetes type 1 and so on, these play a part, right? But then as you are born and grow, other things can disturb your immune system like allergies,
00:08:09
Speaker
activation of certain immune cells, again caused by various toxic compounds, chemicals, heavy metals, excessive inflammation, which again can be caused by these external compounds or bacterial infections, candida, stuff like that, and leaky gut or intestinal permeability.
Dietary Changes for Health Protection
00:08:34
Speaker
This is another thing which
00:08:35
Speaker
can go hand in hand with, again, gut infections, candida, heavy metals, and toxic chemicals. And then inflammation is invariably going to be involved here, right? So the two main, so you have a little bit of a primer, how this kind of stuff can develop. Now, what I wanted to
00:09:02
Speaker
Cover is a couple of the mechanisms because this will underscore the importance of cleaning up your child or your own diet. When I say cleaning up the diet, I mean
00:09:18
Speaker
switching over to organically grown produced food that does not use all these chemical pesticides, poisons, artificial fertilizers that can have some deleterious chemicals in them and herbicides, glyphosate, and of course removing processed foods that are full of emulsifiers and other horrible chemicals as well.
00:09:45
Speaker
So that's one thing. And then the other is cleaning up the environment again from toxic exposure. So switching from aluminum, cookware to stainless steel, cast iron, just buying more natural cleaning products, just so many things. And I have podcast episodes that cover these things in more detail. So the two mechanisms that we'll cover now to get to the meat of this topic,
Food Proteins and Autoimmune Issues
00:10:19
Speaker
They are cross-reactivity, also known as molecular mimicry, and the formation of neoantigens, so new antigens. So cover cross-reactivity or molecular mimicry first. So this is another quote from a paper I cite in my book on autism.
00:10:45
Speaker
quote, due to the similarity of food proteins and infectious agents to human tissues, antibodies produced against the food and infectious antigens may also attack human tissues. So again, this can be triggered by food proteins
00:11:09
Speaker
and infectious antigens, so infections. So this is where we're not talking about gut health and why it's so important, right? Why you have to understand if you or your child have a gut infection, candida overgrowth, very, very common with autistic children, actually. You should know that by now if you listen to my Autism and Children's Health podcast. So now these tissues that can get attacked
00:11:38
Speaker
can be a part of a brain, the gut barrier or anything else in the body as I've already covered, right? So you've got your antibody that is roaming around in the blood, looking for the antigen to attack the bad guy. And before it sees the actual bacterial toxin, let's say, it sees your tissue, your body's tissue, let's say a cell in your nervous system, and
00:12:04
Speaker
It attacks that because it mistakes it for the antigen of the infectious particle or bacteria or whatever it is. Now what can happen here is it attacks the body and this can lead to a vicious cycle.
00:12:22
Speaker
It thinks there's more of these guys and more antibodies get created. So now all the similar looking tissues in the body, there's a higher chance there's more antibodies for them. There's a higher chance they can get attacked and damaged and that causes inflammation, right? Causes further tissue damage. Now other bits can break off from that tissue that
00:12:43
Speaker
because they're not the the full protein they're different now the the immune system may again mistake them for a foreign invader and we'll cover that a little bit later right so basically what you must understand is what
00:13:06
Speaker
What are cross-reacting antigens? And some of the most common ones in food are things like soy, wheat, or cow's milk proteins, and certain heavy metals like mercury, various chemicals that I don't really have the time to get into, and infectious agents again, so bacterial toxins, candida, and viruses allegedly, right?
00:13:36
Speaker
So these are potentially cross reacting foods. Okay. Now the other mechanism that we'll cover briefly is the formation of neo antigens.
Impact of Heavy Metals and Chemicals
00:13:50
Speaker
So these, um,
00:13:54
Speaker
These basically, Neo as in new, right? Basically what happens is when you have like a heavy metal particle or a chemical or whatever other particle, even certain food particles, right? They can actually
00:14:16
Speaker
bind with our own tissues. They kind of like hit them and they get stuck in them. If you can imagine like throwing a brick into a window, that kind of way. Not the best example, but it gets stuck in the tissue, like it crashes into it. So through that, it creates a new structure.
00:14:39
Speaker
or a complex. That's what the researchers call a neoantigen. Now, this neoantigen, because it has a different structure, the immune system doesn't recognize this particular, you know,
00:15:01
Speaker
structure. So this can cause the immune system to react very strongly, right? Now here's another quote from a paper I cite in my book.
00:15:14
Speaker
The act of binding to tissue also breaks down tissue, causing tissue antigens to free flow through the bloodstream. Here the immune system will identify these tissue antigens as unwanted materials and thus make antibodies against them. Once the formation of all two antibodies occurs, tissue degeneration may follow.
00:15:37
Speaker
This is autoimmune reactivity. If the exposure to the environmental trigger is not eliminated, the tissue destruction will continue to the point of autoimmune disease.
00:15:50
Speaker
Okay, so you have your body's tissue, something gets stuck in it. Now you got your antibodies, your immune system creates antibodies because it didn't recognize that as part of the self. You got your antibodies attacking that, that causes damage, inflammation and
00:16:13
Speaker
pieces of tissue, whether that's cells in the, you know, could be the pancreas, it could be any organ really in the body, could be blood vessels, whatever, pieces of that break off. And let's say if it's one, like in the case of a house, if it's a brick,
00:16:36
Speaker
It's very easy to understand that's part of the house. But if it's like several bricks stuck together with cemented mortar, that's a bigger piece. And now the immune system is only used to like seeing either mortar or bricks. It's not used to seeing like six bricks in that particular shape. So it's like, okay, that's something you have to attack. And now the antibodies that get created
00:17:05
Speaker
they, if they spot that pattern of six bricks in the body, let's say, they, that also will start getting attacked. So this is where you can get the, so the, the, um, the more of these triggers there are, the more damage occurs.
00:17:24
Speaker
And then the more degeneration occurs and then that feeds the vicious cycle because now you have more different tissues breaking down, new antigens, more antibodies, more autoimmunity, more damage, more inflammation, you know, further sort of compromise of the gut.
00:17:42
Speaker
further compromise of the blood-brain barrier. And then, you know, once the blood-brain barrier sort of gets breached, you know, we've got a recipe for really, really horrendous disease to occur.
Gut Health's Importance in Autism
00:18:00
Speaker
So you can see now why the old adage death begins in the colon or old disease begins in the gut, you can see why
00:18:17
Speaker
we talk about the importance of the gut. It's linked to pretty much all conditions, or at least it's got a, it's a big, it plays a large factor. And with my work, at least just to give you an example with autistic children, and what I advise parents in my book is if you were to force me to tell you what area is the most important to focus on,
00:18:46
Speaker
it's the first thing I would say is get your child's gut health in order. And if you came to me with as an adult, let's say, and you had like skin problems, or anxiety, or you know what, most things I'll tell you is the first thing we will do is run some tests that look at gut function, whether
00:19:10
Speaker
there is candida overgrowth, whether there's parasites or opportunistic bacteria or pathogenic bacteria that have invaded the gut, you know, or we can look at some, you know, the numbers of the beneficial microbes, are they reduced, so on and so forth, right? And I should mention that if you do need help,
00:19:34
Speaker
If you do have some issues that you want some advice on, get in touch. There's links down below for health consulting for children and for adults, separate pages, check that out. You know, we've had some amazing success with getting people back on track with like
00:19:51
Speaker
a decade or more of irritable bowel syndrome, things like that, autistic kids with pretty nasty bacteria and candida overgrowth and so on and so forth. Even in a few months, you can really have some amazing results. So if you are interested, get in touch with me. Links are below in the description.
00:20:16
Speaker
Yeah, this is why the gut, you have to really protect yours and your family's guts like you would, I don't know, like you would protect the treasure because this is where it's at. And again, this is super important to remember, if you have gut issues, they will not just be physical
00:20:42
Speaker
health problems that you will see. You could have only quote-unquote psychological problems, quote-unquote behavioral issues in children that could be the root of that or one of the cause of factors or contributing factors
00:21:03
Speaker
is very likely to be the gut. So this is what people must understand. It's not necessarily going to be just like you have gut problems, you're going to feel pain in your gut. This is what you have to understand. You have gut problems, you will not necessarily have constipation, diarrhea, gas, bloating, stuff like that. Often you will, but sometimes it could just be a headache. Seriously, you just get a headache.
00:21:32
Speaker
It could be something related to intestinal permeability or leaky gut, food sensitivities and so on. It's what you must understand of sleep problems or moodiness because the bacteria in your gut, they create
00:21:47
Speaker
neuropeptides, neurochemicals, neurotransmitters, serotonin, they can interfere with conversion, like if you have toxic bacteria and their compounds or metabolites,
00:22:02
Speaker
They can interfere with the conversion of certain neurotransmitters, right? Those metabolites. So that can cause strong behavioral effects in the case of autism. In fact, the Clostridium bacteria, anyone can get it, Clostridium difficile.
00:22:19
Speaker
It exudes a particle or it excretes a particle called for creosol and that de-inactivates an enzyme in the nervous system called DBH, dopamine beta hydroxylase. And then, so I believe it's in my book, just off the top of my head, that enzyme,
00:22:48
Speaker
converts dopamine to norepinephrine. And if you have a lot of Clostridia, which a lot of Clostridium difficile, a lot of autistic children do have, I'll tell you. And we can test that on the organic acids test with the Great Plains Lab. So that
00:23:14
Speaker
for creosal metabolite, it inactivates this DBH enzyme. So that causes a buildup of dopamine in the nervous system. And dopamine is extremely reactive. It can cause damage and oxidative stress that can damage nervous system tissue. And can you see now how
00:23:37
Speaker
That can have, like if you damage nervous system tissue, can you see how that will have, you know, neurodevelopmental manifestations in children or potentially neurodegenerative manifestations in older folks, right? So, okay.
00:24:01
Speaker
Just to summarize what particles, to get back to this formation of neoantigen section, what particles we know that can bind with human tissue and create these new neoantigens. These include mercury, aluminum or aluminum, BPA or bisphenol A, formaldehyde,
00:24:26
Speaker
and artificial food colorants are known to do this. Certain dietary lectins and glutenins. So, for example,
00:24:35
Speaker
Gluten is an example of a lectin, which is basically a protein in plants or in organisms. And gluten can actually bind with tissue. So this is why gluten, going gluten free case in free, especially like, for example, for ADHD, autism, anytime there's gut dysfunction in adults, children as well.
00:25:02
Speaker
going gluten-free and even case dairy-free is very often a good idea, at least for a while. Let the gut heal, let the immune system calm down a bit. Now, let me get into, so I just sort of emphasized why the gut
00:25:32
Speaker
is so important to be kept in a healthy state. And we wanna ensure as few toxic particles are allowed to enter your body or your child's body to keep the gut in good check, right? And why we want to test for infectious organisms and do something about them. Or if you can't afford the testing
00:26:01
Speaker
at least invest in like a pathogen eradication protocol, like a cleanse and do that once, twice a year. So I've, excuse me, I've done tests on myself and of course on my family members, friends, obviously clients, but for myself, what I do now is twice a year when the seasons change,
00:26:27
Speaker
uh, spring when spring sort of, when we entered into springtime. So about now in March and, um, September when, you know, we go, we get into autumn. What I do is a, um, basically I do a parasite cleanse. I use various antiparasitic herbs, uh, diatomaceous earth.
00:26:57
Speaker
olive leaf extract, they've got some really good supplements that are readily available and easy to find, fairly inexpensive. So I do that along with the Goldbladder Flush, I've discussed that in the future. There will be a video course on that coming out soon. So I do that a couple of times a year and this protocol, we can do it for a week, 14 days, it depends on if you feel like
00:27:24
Speaker
If you feel like you may have parasites if you're waking up a lot like a three three or so a.m. At night you can't fall back asleep if you have like itchy itchy butt Or so, you know, if you feel like you have got dysfunction you
00:27:39
Speaker
You know, obviously I would recommend working with a practitioner. You don't want to just guess and do kind of, you can, it's very easy to do something, you know, that can cause harm as well. So you need to, you need guidance. I believe, but, um, so what, what I do is a couple of times a year I do this, whether or not I believe I have a,
00:28:00
Speaker
An overgrowth or not because I have had I have had Excuse me. I have had parasites and very high candida And certain dysbiotic bacteria. I've had that a few years ago. So It's it's basically like a Reset I do so even if something when I did that big massive protocol back in 2019 to
00:28:27
Speaker
kill them off, you know, to normalize all that stuff. Even if something survived, or I caught something in the past years being outside, and you will always, you know, have exposures, I just do this like a mini reset every six months or so. And, you know, that, that keeps my gut healthy. You know, if, you know, if, if there is nothing
00:28:51
Speaker
If there's nothing quote-unquote bad in there, taking these herbs, it doesn't have side effects like taking antibiotics or toxic drugs. Curbs may have side benefits in fact, right? So they have anti-inflammatory antioxidant properties and through hormesis they can stimulate antioxidant production in the body and so forth, right?
00:29:23
Speaker
That's the gut stuff. You can see I can talk about this ad nauseam, as you can probably see. I can absolutely chew your ear off on the many different reasons we have to keep our guts healthy. But I almost sort of lost my train of thought there what I was going to talk about. It was the
00:29:49
Speaker
It was the other component.
00:29:53
Speaker
of reducing toxic exposures that I wanted to touch on as we slowly wrap up this episode. So you now understand the importance of the gut because you want this gut barrier to have integrity, to not have permeability. You want that to, because here's the next sort of, let me segue into the toxic substances.
00:30:23
Speaker
If you've got microbiota in good check and you have no bad overgrowth of candida and pathogenic organisms and you have minimal permeability between your gut cells, toxic metals and chemicals now are harder to get into your bloodstream because
00:30:47
Speaker
You have your microbiota, you have your gut cells, there is layers of protection. This is the importance of keeping inflammation low. Now, however,
Cycle of Inflammation and Autoimmunity
00:31:00
Speaker
On the other side of things, if you, let's say, you know, drink water with arsenic and other heavy metals and toxins that you're not filtering out, and check out my previous episode on talking about water distillation, reverse osmosis and the importance of water, obviously clean, pure water.
00:31:19
Speaker
But if you have an onslaught of toxins from the diet in the water into your body because you're not investing in organically grown food or some folks just don't have it available to them.
00:31:38
Speaker
you know or you eat a lot of processed foods or your child eats a lot of processed foods which have chemicals like there's more than 2500 chemicals in foods that are used regularly from emulsifiers to you know preservative stabilizers food colors
00:32:02
Speaker
flavors, excitotoxic things like monosodium glutamate and many others, right? So even if you have a pristine gut now and there's no leakiness or no permeability and it's in good shape, if you start eating foods that are contaminated with heavy metals and these chemicals, now you can actually start, you can lay the foundations for autoimmunity
00:32:30
Speaker
through basically the following. You've got these heavy metals, chemicals. These can damage the gut, right? They can get stuck into tissues. They can cause tissue damage. That causes inflammation. That causes immune system activation. That can cause, again, talking about the vicious cycle, further inflammation,
00:32:59
Speaker
Now you have new neoantigens, now you're creating more antibodies, now there's more tissue damage, now the gut becomes leaky. And now, if you continue these environmental, these triggers that you're taking, heavy metals, chemicals, whatever it is in the diet, in the water, if that continues, now you've breached the gut barrier. This is where things can get potentially nasty for a person.
00:33:27
Speaker
You've got the blood barrier, sorry, you've got the gut barrier breached. Now these things are getting into your bloodstream. And this goes back to the stuff I already covered. So they're tagged as antigens, antibodies,
00:33:51
Speaker
and then further immune system activation, further inflammation, further tissue damage. And again, so this is another way to enter this vicious cycle. So even with a perfectly healthy gut, if you don't do something about toxic exposures, you are now potentially getting into this vicious cycle. Okay. So this is why a pristine diet, especially when someone has a condition like autism or
00:34:17
Speaker
Alzheimer's or you know, IBS or Frank autoimmune conditions. This is why diet and environmental exposure are the most important things in any, any, think about any situation you can tell me.
00:34:35
Speaker
I don't care what level of health we're talking. Are we talking perfect health of an athlete or extreme, you know, even cancer and just extreme disease? The first things you want to get right are
00:34:57
Speaker
decreasing toxic exposures, reducing these environmental triggers, and improving gut health and the diet. So I guess it's three things though, but you understand what I'm talking about. So this is the other kind of vector that can lead to autoimmunity over time. And that's not all, unfortunately.
00:35:28
Speaker
Here's the thing, the gut barrier, the tissue of that, so the cells and the tissues that create the gut barrier, they actually use some of the same proteins as are used in the blood brain barrier, right?
Neurological Impacts of Autoimmunity
00:35:49
Speaker
And the blood brain barrier is again tissue in regions of the brain that protects parts of the brain from
00:35:58
Speaker
toxic onslaught basically, right? So if you have antigens or neo antigens that are tagged by antibodies by the immune system that are to the, let's say, okay, here's the example. You got, you know, some tissue damage inflammation in the gut pieces of the
00:36:26
Speaker
the gut barrier get broken off and these are tagged. The antibody as it circulates around your circulatory system, your blood circulation system. If it is in the vicinity of the blood brain barrier, it can actually now mistake
00:36:51
Speaker
tissue of the blood brain barrier as that antigen that it was made to find an attack, you know? So now you've got your blood brain barrier can start getting attacked, right? And once the blood brain barrier is open,
00:37:10
Speaker
And not necessarily just the blood-brain barrier, right? Any time the immune system targets neurological tissue, so that could be nervous system tissue in your central nervous system, for example, and stuff like that, or peripheral nervous system, when if this goes long enough and you start creating antibodies for neurological tissues, now,
00:37:38
Speaker
that damage as it builds, as it builds, you know, if it happens for a while, let's say you catch it six months in or whatever, and you heal the gut, you know, reduce toxic exposure, so on, do all this good stuff, maybe you don't feel anything. But if it goes unrecognized for months and months and years,
00:38:05
Speaker
Now this damage to the nervous system or these neurological tissues can manifest as behavioral issues, movement disorders, communication difficulties. So again, to delineate between children and adults
00:38:28
Speaker
With children, we have neurodevelopmental type issues, conditions, because the brain nervous system and all these sort of systems communicating and working in sync, they're not fully developed. So that manifests as autism and things like that, right?
00:38:51
Speaker
In some people, like I'm not saying every autistic person or every autistic child has neuro-ultimunity or neuro-inflammation and so on, but it is, there is a component, there is a subset of children that do have this, this, this is what I'm talking about.
00:39:11
Speaker
is from my research on autism. But again, it applies to folks of all ages and stages, because in terms of older folks, we have
00:39:29
Speaker
various conditions related to neurodegeneration. We have Alzheimer's, it's the easiest thing to list. I honestly don't care much for learning too much about the thousands of different conditions and so on because
00:39:50
Speaker
Let's say, quote-unquote, the best way or the way to get a person healthy. The principles are pretty much the same, no matter what they have, with obviously some caveat to some complexity there. But on a high level,
00:40:05
Speaker
It's really about diet, lifestyle, environment, water, you know, toxin reduction. So the point is, in older folks, this can be like ataxia, you know, like when loss of coordination in movement, loss of speech, you know, things like that, just kind of dementia, right? So this is what you must understand. And again,
00:40:35
Speaker
I don't want my podcast and my content to be doom and gloom.
00:40:41
Speaker
I do want to offer, as much as I educate folks about staff issues, I want to offer solutions and a way forward. And this is really, I suppose, this is what we have to extract from today's discussion of this issue. Let me just before I continue that thread, just want to end the
00:41:13
Speaker
the, give you one last citation from a study. Um, actually two, I'll give you two. So in terms of this is again, from my book on autism, quote, from, from a research paper. Quote, the earlier the environmental triggers are detected and removed, the better will be the clinical conditions of ASD patients. Right. So the earlier the environmental triggers are detected and removed.
00:41:40
Speaker
And then another quote from a research paper called, while a panacea for such a heterogeneous disorder may never exist, evidence suggests that manipulation of the immune response could improve core features of ASD as well as associated aberrant behaviors.
Removing Environmental Triggers
00:42:01
Speaker
Okay, the language is not very PC in a lot of these researchers' papers, but point is,
00:42:09
Speaker
Immune system dysregulation, that's why it's chapter two of my book. Immune system dysregulation is a huge part of autism and many, many conditions, you know, allergies and, uh, God, you can just, uh, basically any auto immune type thing, you know, there's,
00:42:33
Speaker
The music and here's the thing i know i keep going back to the gut but you got sixty to seventy percent of your immune cells are in and around co located in the gut.
00:42:49
Speaker
which came first, the chicken or the egg, which came in terms of health issues, which came first, the immune dysregulation or the gut dysfunction. Because immune dysregulation can cause gut dysfunction. Gut dysfunction will cause immune dysregulation if left unchecked.
00:43:10
Speaker
How do you know if your or your child's immune system is dysregulated? So I'll tell you some of the most common physical clues. So food allergies, food sensitivities. And again, let me stress this. You will not necessarily know. You have a food sensitivity just by even monitoring your reaction after food. It won't necessarily
00:43:38
Speaker
appear as symptoms like physical symptoms, you know, or if it's if you're in the early stages, you might have no symptoms. It might take months, sometimes years for you to actually get symptoms. And again, they don't have to be gut symptoms. Many, many new, you know, sleep, skin problems, headaches, mood stuff, neurological stuff.
00:44:07
Speaker
It can manifest as only that and you may even notice nothing related to your gut and many people are like that and sometimes it takes me getting them a food sensitivities test
00:44:22
Speaker
And then they see like they have like three or four or five foods are like off the charts in terms of antibodies, not because you have like the delineation on these tests, you have like, you know, safe or minor, you know, you have yellow, you know, green is low, you know, yellow, orange, red and then red. And then some people are off the charts, seriously, like for, you know, gluten, for example, or
00:44:51
Speaker
One that is very common I've seen it in adults and children is meat glue. If you processed meat, meat glue is actually something we can test for and a lot of people react very reactive to it. So again, goes back.
00:45:09
Speaker
well and I do I do actually I do have an episode on gut how to fix your gut it's called I believe on my connecting minds podcast and the reason I'm saying what podcast it is on is because I will publish this episode probably to two podcasts of mine the autism and children's health and connecting minds and I'm also
00:45:34
Speaker
planning on starting a third podcast, just Children's Health, the Children's Health podcast. So in the future, you can check that out. That will be just more general Children's Health. But yeah, so
00:45:48
Speaker
So just to kind of go back to, I keep going on some tangents, I'm sorry if it's hard to follow. So common physical clues that your child or your own immune system is dysregulated include, again, food allergies or sensitivities, obvious adverse reactions to foods, chemicals or medications.
00:46:12
Speaker
chronic gastrointestinal symptoms. This is the most obvious thing. Constipation, diarrhea, excessive gas, bloating. But let me just emphasize. So these chronic gastrointestinal symptoms of constipation, diarrhea, excessive gas, or bloating are indicative of gut issues, obviously.
00:46:36
Speaker
But the points I'm covering here are these are clues that your child or your own immune system is dysregulated. So if you have gut problems and you've had them for a number of months or more,
00:46:56
Speaker
then it is even more likely that you have some type of immune system dysregulation. And left unchecked, over time, that things can happen, especially if you just continue on a path of poor diet, a lot of stress, working too hard. There's so many things, maybe you're going to the gym, over training, these things will over time build up.
00:47:27
Speaker
And another common clue is when children especially, so a lot of recurrent infections, like ear infections, chronic sinusitis, or if you get sick a lot, like if you get a cold or the flu like three, four times a year, listen, don't let anybody tell you that's normal, or that you have kids and kids are bringing you viruses,
00:47:53
Speaker
from school and listen listen that those are I'm sorry excuse my language those are bullshit excuses the reason people get sick a lot with you know minor cold and stuff like that is not it's not because your kids okay it's because
Taking Responsibility for Health
00:48:12
Speaker
I'm going to go out on a limb and of course we can do lab tests and stuff like that and analyze diet and lifestyle. But I'll tell you in most cases, it's because your health is not as optimal as it could be. It's diminished.
00:48:30
Speaker
You probably have some type of gut dysfunction you're not aware of. You are probably pushing yourself too hard. You're not eating well or well enough. You're probably getting a lot of toxic exposure from food, from traffic and stuff like that. It could be other factors as well, of course.
00:48:53
Speaker
But let's stop making excuses that we get sick a lot because our children are bringing us viruses back from school and stuff like that. Let's get our health in order.
00:49:05
Speaker
And you see that for me, not that I'm surprised or disappointed. We've had a very tough couple of years with my wife because we had a child and that was obviously sleep.
00:49:25
Speaker
sleep sort of goes downhill and diet definitely wasn't as good as before when we had time at least for a while now it's much much better of course it just we had that we had like a the first sort of year was was a little bit survival mode basically survival mode so we're starting to crawl out of that place but you know and I understand why people were in
00:49:54
Speaker
in the stage there i'm not judging or anything but i'm just saying we let's not make excuses let's take responsibility and if we want to and fix things we can. Okay so.
00:50:08
Speaker
Final point, and there will be more content related to this and other similar topics in the future. Don't worry about
Signs of Immune Dysregulation
00:50:16
Speaker
it. If this was interesting to you, there will be much more interesting things coming up. But let's just briefly talk some of the things that in the future will cover a little bit more. So what are the
00:50:33
Speaker
So in terms of children, basically, if the points I covered above
00:50:45
Speaker
are present in a person, child or adult, that are clues that there is some type of immune system dysregulation. So again, food allergies, sensitivities, adverse reactions to foods, chemicals, medications, chronic gastrointestinal symptoms, recurrent infections. If these are present and it does signify immune system dysregulation,
00:51:13
Speaker
Some things that can be done, ideally with the help of a practitioner, of course, that knows what they're doing is, for example, like you can go to your doctor, especially for children, if you haven't done an allergy test, identify any allergies and eliminate allergens from the diet and environment, right?
00:51:38
Speaker
in terms of adult and children's health, identify food sensitivities. This is something that really is super, super prevalent, right? Super prevalent and, you know, for
00:51:55
Speaker
$150, $200, you can do a food sensitivities panel that can test for like a couple hundred foods. I do one, I send one to my clients where you receive the, it's like a little, basically it's a card, like a paper card, you just poke
00:52:17
Speaker
Prick your finger and you just put a few spots of blood on it. Yeah, let that dry for a day. You package that or you put that in an envelope, send it back to the lab and it's a really good test.
00:52:34
Speaker
and you will quickly know what foods to remove from your diet or from your child's diet because these foods are causing inflammation, immune reaction, and they're contributing to the vicious cycle. What you want to do is identify as many of the factors as you can and stop those things from progressing to stop the vicious cycle. The other thing you can do
00:53:07
Speaker
is remove other potentially cross-reactive or inflammatory foods and additives. So again, processed foods, that's junk. Stop buying that junk, okay? Potentially cross-reactive foods, if you eat soy, let's say you did a food sensitivity test, but for example, wheat or dairy or soy, or all three didn't come back as reactive, but other things did. You may want to
00:53:37
Speaker
while your gut is sort of getting in better shape, you may want to go gluten free, or casing free, or both, or remove soy, or corn, or all grains. A lot of people, listen, grains can be very inflammatory, especially how we are over consuming them and not preparing them in the ancestral way. So you may want to,
00:54:01
Speaker
do let's say you do have got dysfunction and you know we find out on the test you may want to just remove grains for six months or maybe more depending on how bad how bad things are of course. Now goes hand in hand with the next point you want to identify and address gut infections that are causing immune activation and again you won't necessarily have
00:54:25
Speaker
super visible symptoms like with candida with you know a lot of people I actually I would say
00:54:37
Speaker
The majority of people that we have through lab testing in my practice that we have found some type of dysbiotic marker on a test like candida, clostridia difficile, stuff like that.
00:54:56
Speaker
they didn't actually have overt gut dysfunction like you know your common symptoms like constipation, diarrhea, pain when eating, bloating, gaseousness and stuff like that so it very often is hidden this stuff is hidden yeah and then this next point goes hand in hand with the previous one you want to support gut healing with a healthy organic diet
00:55:20
Speaker
and supplements, supplements really help speed up the process. There's just certain things you won't be able to get enough of from your food, right? And supplements is something I've done a ton of research into and I'll cover in a lot more detail in the future. So not going to get into it now. And then in some cases when we're talking about specifically suspected alter immunity or like a family history,
Preventing and Managing Autoimmunity
00:55:48
Speaker
about immunity. There is some tests that for clients in the USA and Canada, maybe Mexico, I can't remember if Mexico also is included, but USA and basically North America, Canada and USA, we can run
00:56:06
Speaker
pretty specialized, quite advanced tests that test for autoimmune antibodies. So antibodies that target specific tissues, like neurological gut tissues. So it's a pretty advanced test, not the cheapest thing either. But in some cases, you know what, it's worth running because in some cases, these things can
00:56:30
Speaker
Once you reach a certain threshold, they can progress or cause degeneration super quickly. As we've already covered today, you want to
00:56:42
Speaker
Identify, reduce environmental triggers and get the gut healthy as quickly as possible and keep it that way. Don't just regress to after a year or whatever, you feel better and then you start, oh, have a pizza here, oh, I'm going to have an ice cream there. And then slowly that vicious cycle begins expanding and becoming more serious again.
00:57:10
Speaker
So that, I will leave it there.
Conclusion and Resources for Further Learning
00:57:15
Speaker
I think I covered enough stuff and it's been an hour. If you are still listening, thank you so much for tuning in. Check out the links below. I have three video courses. This is more for children's health related with a focus on autism, but any parent would find value in these courses. You will learn not just
00:57:39
Speaker
valuable stuff for your children, but for your just health in general. It's on the gluten-free case, in-free diet, nutrient supplementation and the health challenges in autism. So these three courses are available for free. It takes less than a minute to sign up to my member platform on the free tier. You get instant access to those. There's at least six or seven or more hours of content there, I believe.
00:58:04
Speaker
And you can have that. And there's probably by the time you hear this in the future, if this is the future, not not the next few days after I publish this, there will be more content there, free content for you to, you know, look, you know, look over read. And then my website should have a have a start organizing things into specific health topics that you may want to check out again, not
00:58:31
Speaker
Not if you're hearing this now, today, or tomorrow when I publish it, but soon. So I will, of course, let you know again in the future. Again, thank you for tuning in to the podcast. Christian Jardinoff signing off. See you on the next one.