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Heart Disease: What's the Major Culprit?
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Transcript
Introduction to Heart Disease and Misconceptions
00:00:01
chrisyzen
Hey, it's Christian Northernoff. Today, let's talk about heart disease, how to prevent it, if it's even possible, what potentially causes it, what probably doesn't, despite a lot of mainstream propaganda that it does.
Critique of Mainstream Health Guidelines
00:00:18
chrisyzen
And as I explained in my book, how to actually live longer, volume one, if you listen to mainstream health information, if you listen to the government,
00:00:31
chrisyzen
and their guidelines about health and diet and nutrition, you unfortunately are screwed with a capital F. Case in point.
00:00:44
chrisyzen
i i um ah I typed into DuckDuckGo how to prevent heart disease and of course a lot of the usual articles pop up and I open up a couple just to give you what the mainstream narrative is and then we can contrast it a little bit. So
Debunking Myths about Salt, Sugar, and Alcohol
00:01:06
chrisyzen
CDC, the Center for Disease Creation in the USA,
00:01:11
chrisyzen
they say choose healthy foods and drinks okay you can choose healthy habits to to help prevent heart disease what are these healthy foods and drinks so choose healthy meals and snacks to help prevent heart disease and its complications be sure to eat plenty of fresh fruits and vegetables and fewer processed foods okay so far so good i guess then it says eating lots of foods high in saturated fat and trans fat may contribute to heart disease so they're so they're saying directly that eating lots of foods in high in saturated fat will contribute to to heart disease
00:01:49
chrisyzen
And then eating foods high in fiber and low in saturated fats, trans fat and cholesterol can help prevent high cholesterol. Okay. As if, as if having a high cholesterol causes heart disease. Okay. Then limiting sodium AKA salt in your diet can also lower your blood pressure. So limiting salt is probably contributing to a lot of health problems people are experiencing nowadays.
00:02:19
chrisyzen
and limiting sugar in the diet can lower your blood sugar level to prevent or help control diabetes. So they're saying that carbohydrates or sugar causes diabetes which is bullshit.
00:02:30
chrisyzen
it's actually overweight or a lot of stress these are the main things that actually cause diabetes or a combination of both having a lot of circulating fat in the bloodstream is what causes diabetes actually and do not drink too much alcohol which can raise your blood pressure okay that that that was a good one you got one you got one properly guys well done Keep a healthy weight, get regular physical activity,
Industry Influence on Health Guidelines
00:02:57
chrisyzen
don't smoke. Great, geez, wow, they're still telling us not to smoke.
00:03:01
chrisyzen
as if these are like the best the brightest minds in the world in these ah organizations that they're they're telling us check your cholesterol control your blood pressure manage your diabetes take your medicines as as directed gee thanks work with your health care team so make sure you keep going getting your medicines and whatnot let's see then heart org so the american heart association whom by the way in 1948 got a bunch of cash from Procter & Gamble who in 1911
00:03:38
chrisyzen
came out with the cotton seed vegetable sort of shortening Crisco and surprisingly enough since then heart disease and cancer has increased dramatically in the USA and they sponsored the freaking cotton seed shortening people sponsored the American Heart Association.
00:04:04
chrisyzen
and lo and behold in the next decade and in the 1950s cholesterol and saturated fat were suddenly were vilified as the culprits and then of course all of these vegetable oils were considered marketed as heart healthy because they can lower your cholesterol so let's see what heart.org the american heart association tell us about how to prevent heart disease and stroke know your risk number one know your risk Knowing your risk factors can help you and your health care team decide on the best treatment plant for you. Eat a healthy diet, center your eating plan around vegetables, fruits, whole grains, legumes, nuts, plant-based proteins, lean animal proteins and fish.
00:04:54
chrisyzen
Make smart choices like limiting refined carbohydrates, processed meats and sweetened drinks. Use the nutrition facts table and packages to ah blah blah bollocks. Be physically active. Move more. The doubts should get at least 150 minutes of moderate intensity aerobic blah blah. Watch your weight. Yeah, watch your weight as if that's gonna help a lot. Lose weight if you're overweight. I mean just absolutely mind-blowing the ingenious ideas, guys, thank you so much, live tobacco free, manage your conditions, take your medicine, yeah, make sure you take your medicine, your statins, and your blood sugar meds and all your blood sugar and your blood pressure meds, and be a team player, you know, be a team player. Okay, don't be an ass.
Omega-6 Vegetable Oils and Heart Disease
00:05:40
chrisyzen
Your healthcare care care team wants to help you go and get your medications. Okay, okay. Thank you.
00:05:48
chrisyzen
live well today for a healthier tomorrow. Bottom line, this was just like mind-numbingly stupid. I'm sorry, but it's um infuriating. The best minds, the PhDs, the MDs, or is it the, the, they're in the pocket of industry. And, and let's, let's just say the medical industrial complex, the big agriculture selling all of these subsidized seed oil products. I don't want to actually talk about what's really causing heart disease. So so we know about the cholesterol hypothesis since the 1950s of heart disease, but there's a dude called James D'Nickel Antonio, pretty cool guy. He's a researcher, scientist, and um him and another person, James O'Keefe,
00:06:44
chrisyzen
They published a paper in Open Heart, the journal Open Heart. ah
00:06:51
chrisyzen
in 2018. And that that paper is titled Omega 6 Vegetable Oils as a Driver of Coronary Heart Disease, the Oxidized Linoleic Acid Hypothesis. right So the cholesterol hypothesis, you know, it actually kind of started when they gave rabbits which don't even eat cholesterol containing foods and meat and whatever.
00:07:16
chrisyzen
they gave them a bunch of I think I forgot what it was it was a cholesterol specifically but it was a high cholesterol sort of boldest that they were given and then they ah developed atherosclerosis or plaques and whatnot so that's kind of the where it all started I think that that that research was done in Russia but but that's kind of where it starts you know so yeah they might find ah cholesterol in these atherosclerotic plaques therefore cholesterol caused it but what's what other researchers have been saying is that the cholesterol is there as part of the healing process so there's something causing injury to the vascular endothelium to the blood vessel lining of the arteries and um the be that inflammation or whatever other insult
00:08:10
chrisyzen
and then obviously the body initiates repair and healing processes so part of that because cholesterol is so integral to every cell has so much cholesterol and it's like it's membranes it's a structural um component it is what becomes vitamin D but it is the backbone really of what um our us steroid hormones are so testosterone progesterone DHEA you know all of these protective hormones they are made from cholesterol so they basically vilified a super integral part of
00:08:50
chrisyzen
you know what makes us us so pretty insane so but these guys are basically taking a slightly different approach here so they're actually asking what is causing that that injury that then results in these eventual build up builds up build ups of black and calcification and stuff like that right So basically, I'm and im just going to read excerpts from this paper. So the intake of omega-6 vegetable oils, particularly soybean oil, began to increase in the USA starting in the early 1900s, at a time when the consumption of butter and lard was on the decline. And this caused
00:09:38
chrisyzen
ah more than two-fold increase in the intake of linoleic acid, which is the main omega-6 polyunsaturated fat found in vegetable oils, the main omega-6. And it now makes up eight to 10% of total energy intake in the Western world. So your average person on the street in the States consumes eight to 10 of their daily daily energy intake as linoleic acid. So, you know, that's a lot of Omega-6s.
00:10:13
chrisyzen
And basically from 1956 to 2008, the amount of linoleic acid found in Americans adipose or fatty tissue ah basically increased by 2.5 fold or two and a half fold. And This linoleic acid has a half-life of approximately two years in our fatty tissue, so when you have whatever, a donut, those omega-6s in there that get stored will remain in the body for multiple years.
00:10:57
chrisyzen
And keep in mind, so over the last 130 years or so, as we have started consuming more and more of these vegetable or seed oils, all of the diseases have skyrocketed, right? So I need to find that it's in my book somewhere. So um just let me pause for a second.
00:11:21
chrisyzen
So yeah, so if you go to PubMed, where you can search for the all the studies getting published, and if you search for myocardial infarction, which is the medical term for heart attack, and if you narrow the search between the first record in 1916 to 1940, only 14 papers were returned when I did this when I was writing my book.
00:11:47
chrisyzen
14 papers documenting some aspect of or including the the the keywords myocardial infarction 14 papers from 1916 to 1940 and atherosclerosis returned only 12 studies for a similar period but if you look for something like diabetes um more than a thousand results are listed up to 1940 and the earliest record on PubMed is from 1788. Obviously a lot of records were being kept even before the internet, even before kind of electronic storage, so they
00:12:34
chrisyzen
they have added them to PubMed, right? So if you search for diabetes, the earliest record is from 1788. There's a thousand records talking about diabetes in some way, shape or form until 1940. And if you look for cancer,
00:12:55
chrisyzen
you got 2600 odd papers up to 1940 and the earliest record is from 1783 so what we are being engineered to believe is that heart disease is super common it's just a fact of life and
00:13:22
chrisyzen
the the
Historical Perspectives on Heart Disease
00:13:23
chrisyzen
you can see clearly by this it's that it was basically almost unheard of before the the 1900s it was basically unheard of people were dying of different things probably I guess malnutrition I suppose a lot of people that were kind of lowly plebs quote-unquote like most of us they were working very hard just to eke out of subsistence which definitely drains a person if you're um like that ah I suppose infections
00:14:00
chrisyzen
acute kind of infections accidents these would have been probably more much more prevalent prevalent killers um but heart disease probably wasn't one of them and the thing is if you if you go I did this experiment a couple of months ago I went to chat GPT And I asked it to give me the records. It will only give me the last five years how many deaths there were from heart disease recorded. You have to go dig deep into the archives to actually see how many people are dying from heart attacks. And the numbers are nothing like today in America. Now it's like more than.
00:14:37
chrisyzen
five or six hundred thousand per year over the last five years or or more and the it just wouldn't any I tried multiple times to get get the data out of it, it just would not it gave me fake data in these tables and it admitted it did um so they they don't want people to know that heart disease is an artifact of the last of this modern society we're in over the last you know hundred 30 odd years. So what what is very evident is that it it it's at least it's very well correlated, much more car much more so than carbohydrates, sugar, because sugar has been around for a long time, hundreds and hundreds of years, more than a thousand years, and grains have been around for like 10,000, 12,000 years, so it's clear that
00:15:34
chrisyzen
If you zoom out at least, it's the ever increasing consumption of vegetable seed oils is what correlates ah but the more it's it's what most correlates with the rising heart disease. So these guys this this paper is freaking long.
00:15:57
chrisyzen
and they have ah a big table box one which has a bunch of different references in there where they they have studies obviously cited for for them all but here's the the i'm just going to go over this very quickly for you just you get a better picture of why they think linoleic acid being oxidized is the the biggest culprit behind coronary heart disease. So box one evidence implicating omega-6 rich vegetable oils as a causative factor in atherosclerosis and coronary heart disease. So
00:16:39
chrisyzen
Greater amounts of linoleic acid oxidation products are found in LDL and plasma of patients with atherosclerosis. Greater amounts of linoleic acid oxidation products are found within atherosclerotic plaques. And the degree of oxidation determines the severity of atherosclerosis. So because linoleic acid is a poi unsaturated fat,
00:17:04
chrisyzen
it is susceptible to this oxidation or peroxidation, which is a damaging process. So these are very easily damaged um or oxidized ah molecules. So the the when that happens, they damage things around them. So if they're stored in the these LDL lipoproteins, the the bad cholesterol, you know as it's called, they can damage those. If they're in the blood vessels and there's damage to one, it can damage those around it. right So the more of these you have in your tissues, the more susceptible you are to damage to inflammation and to oxidative stress. Also keep in mind that
00:17:50
chrisyzen
linoleic acid is a precursor to inflammatory molecules in the body, prostaglandins. And the more of it you have, the more inflam inflammation potential you have in the body. And the more inflammation potential you have, the more oxidative stress potential you have because they feed into each they feed into each other.
00:18:09
chrisyzen
so the this over decades as a person kind of continuously eats these and perhaps they're they're not eating supplementing and they're stressed and they're exposed to other toxins and whatever else over time this causes damage to the not not just to the blood vessels to a lot of other tissues and organs of course and cells the brain and everything else but um specifically this causes damage to the blood vessels and that is what eventually starts becoming atherosclerotic plaques right and that that's kind of an artifact of the attempted
00:18:56
chrisyzen
healing
Omega-6 Fats and Health Risks
00:18:57
chrisyzen
processes by the body or repair process. um Other points from from from these guys. A diet higher in oleic acid, which oleic acid is well basically the predominant monounsaturated fatty acid in olive oil. So a diet higher in oleic acid or lower in linoleic acid decreases LDL susceptibility to oxidation.
00:19:24
chrisyzen
endothelial cells oxidize LDL forming linoleic acid hydroperoxides. Linoleic acid is the most abundant fatty acid in LDL and is extremely vulnerable to oxidation being one of the very first fatty acids to oxidize. So the more of it again you have in your body, in your LDL lipoproteins and in your brain, in your heart, in your blood vessels, in your skin, the more Vulnerable those tissues organs are to damage from oxygen just from regular metabolism heat UV light or light in general, right so That this is the biggest Longevity lever that you can pull honest to God like I I've looked into so many different aspects like the toxins and
00:20:22
chrisyzen
yeah emfs and whatever else this if you can get this under control and again it takes years you have to really play the long game here so you have to really get your diet dialed in and maintain it right no no excuses just be an adult about it you know and say you know what this is not worth it it's not worth it and the older a person gets the more to start to realize that it's a small price to pay to make a few dietary exclusions or substitutions in order to reduce these damaging processes that these Omega-6 fats are a major culprit in. Also, the Omega-3s are an issue. you know they They are also very prone to to this peroxidation process, even more so than Omega-3s. But if you have a lot of Omega-6s,
00:21:14
chrisyzen
they're going to once peroxidized any omega threes around them are also very much, much vulnerable to this peroxidation reaction, ah chain reaction. Okay. Then continuing with these guys, ah tidbits. So a meta analysis of randomized control trials in humans found that when saturated fat plus trans fat is replaced with omega six fat, high in the no lake acid,
00:21:43
chrisyzen
There is an increase in all cause mortality, ischemic heart disease mortality, and cardiovascular mortality.
00:21:54
chrisyzen
Excuse me. So they, that was the Sydney Diet Heart Study. They used, so it was called use of dietary linoleic acid for secondary prevention of coronary heart disease and death.
00:22:10
chrisyzen
evalu evaluation of recovered data from the Sydney Diet Heart Study and updated meta-analysis. So it was 458 men age 30 to 59 years with a recent coronary event and the intervention was replacement of dietary saturated fats from animal fats, common margarines and shortenings with omega-6 linoleic acid from safflower oil and safflower oil polyunsaturated margarine controls receive no specific dietary instruction or study foods they're just eating they continued eating whatever the heck they were eating which
00:22:54
chrisyzen
because that was in kind of 1966 to 1973 it was likely to be you know butter and the the the regular things although by that time the seed oils were still were gaining a lot of tractions already sure um so then the outcome measures all cause mortality cardiovascular mortality and mortality from coronary heart disease is what they were measuring and the results were that the intervention group of 221 men had higher rates of death than controls so that the safflower oil
00:23:35
chrisyzen
and safflower oil, polyunsaturated margarine, which you can substitute safflower oil for sunflower oil, so soybean oil. They're all very similar in terms of omega-6 and other fatty acid composition. um So it doesn't matter what you replace it with. It's unlikely to to be a much better result. So they had higher rates death of death the controls.
00:24:06
chrisyzen
uh 17.6 versus 11.6 percent uh also higher rate of cardio wait sorry so they had
00:24:32
chrisyzen
the sorry the So the conclusion here was advice to substitute polyunsaturated fats for saturated fat is a key component of worldwide dietary guidelines for coronary heart disease risk reduction. However,
00:24:49
chrisyzen
clinical benefits of the most abundant polyunsaturated fatty acid omega-6 linoleic acid have not been established. In this cohort, substituting dietary linoleic acid in place of saturated fats increased the rates of death from all causes, coronary heart disease and cardiovascular disease. An updated meta-analysis of linoleic acid intervention trials showed no evidence of cardiovascular benefit. These findings could have important implications for worldwide dietary advice to substitute omega-6 linoleic acid or polyunsaturated fats in general for saturated fats.
00:25:33
chrisyzen
These findings could have important implications for worldwide dietary advice to substitute omega-6 linoleic acid or polyunsaturated fats in general for saturated fats.
00:25:46
chrisyzen
um So this is why earlier when I was reading that um both of those CDC and the American Heart Association articles drivel nonsense, um they didn't say anything about polyunsaturated fats. Did you notice? They only said limit saturated fats.
00:26:07
chrisyzen
because that's the spiel that they've been saying for decades and decades now but they used to say replace them with polyunsaturated fats they used to say that but now they're not saying that because they're very gradually changing they took away the cholesterol thing uh the the aha the american heart association they took the cholesterol thing um ah they stopped they stopped kind of also saying that the omega-6 seed oils vegetables are heart healthy they also stopped doing that because just the evidence has been accumulating and then they are just backtracking enough
00:26:51
chrisyzen
but still leading people astray so they they continue to get sick and do so they don't live healthy long lives. they don't want to They don't want you to live a healthy long life. They want to you to get sick soon into your adulthood and keep going for treatments and chemicals and procedures. And don't die too fast because there's a a lot of value to be extracted from you.
00:27:19
chrisyzen
But don't live too long either because, you know, the the whole pension plan scheme, that's that you're not really very useful if you're not making money and paying taxes and and just, you know, living off of whatever social payments. Right. So that that that's not very um good for business. So that's what they want. Right. that That is why they are not telling you the truth. But they're also covering their ass. So then there's not too much backlash.
00:27:50
chrisyzen
because now if someone goes and reads all of this about potent saturated fats, and then goes to them and say and says, ah why are you recommending this one? All of this data here shows XYZ harm. the they're They're kind of in you know in ah in a pretty tough spot. So they have obfuscated the thing. And if someone says, oh, but like 10 years ago, 20 years ago, you were saying eat the heart healthy, Omega-6 seed oils, whatever.
00:28:18
chrisyzen
They'll say ah but like you know the the science has changed, so keep up, Johnny. Okay, what else? ah So that was that meta-analysis just to restate the the replacement of the saturated fats with omega-6 fats from the safflower oil caused an increase in all-cause mortality, cardiovascular mortality, and ischemic heart disease mortality.
00:28:47
chrisyzen
The next one is more of like mechanisms and stuff. So the oxidation of linoleic acid in LDL leads to conjugated dienes, which some are known as malondyldehyde and four hydroxy non-anal.
00:29:03
chrisyzen
which covalently bind to ApoB altering its structure and creating oxidized LDL. Oxidized LDL is no longer recognized by the LDL receptors on the liver, but by scavenger receptors on macrophages, causing monocyte infiltration into suband into the subendothelium foam cell formation and eventual atherosclerosis. And it all started with this linoleic acid,
00:29:28
chrisyzen
Omega-6 polyunsaturated fat oxidizing and damaging and changing the structure of this LDL. So then it's no longer recognized by the liver's LDL receptors, but it's then the macrophages, which are ah blood cells, white blood cells. They, this causes this monocyte infiltration into sub and the sub endothelium. And this eventually leads to atherosclerosis.
00:29:56
chrisyzen
Then oxidation products of linoleic acid including 9HODE and 13HODE are found in infarcted tissue. Ultrasound of the carotid arteries in healthy patients who have high 9HODE in LDL have signs of atherosclerosis. The increase of 9HODE begins between 40 and 50 years old prior to the clinical manifestations of atherosclerosis.
00:30:26
chrisyzen
9-HODE is a good indicator of oxidized oxidized LDL, especially if other causes and of inflammation are excluded. An increased oxidized lsdl LDL and hence level levels of 9-HODE and 13 HODE in LDL found in patients with rheumatoid arthritis may explain why they have an increased risk of heart disease. 9 and 13 HODE stimulate the release of interleukin-1b from macrophages. therlin The acid metabolite 9 HODE is a strong promoter of inflammation
00:31:09
chrisyzen
and hence may be both a marker and inducer of atherosclerosis. Susceptibility of LDL to oxidation correlates independently with the extent of atherosclerosis.
00:31:24
chrisyzen
linoleic acid free fatty acids and hydroxy acids such as 13 HOD can induce direct toxic effects to the endothelium causing an increase in inflammation reactive oxygen species and adhesion molecules exposure of the endothelium to linoleic acid has been found to increase LDL transfer across the endothelium an essential step in the atherosclerosis process.
00:31:57
chrisyzen
Oxidized linoleic acid metabolites, ox lambs, are recognized by immune cells and can recruit monocytes neutrophils to atherosclerotic lesions. Ox lambs are considered a dangerous signal activating innate immune cells which are involved in atherosclerosis formation.
00:32:16
chrisyzen
linoleic acid is the most abundant fat found in atherosclerotic plaques and this has been known since at least the 1960s
00:32:32
chrisyzen
But a lot of marketing dollars, of course, can remedy knowing things like that. Oxidized linoleic acid but not oxidized oleic acid is found in atherosclerotic plaques.
00:32:49
chrisyzen
By the way, so a lot of why olive oil and whatever is touted as so healthful is because of some of these mechanisms where it's a lot less peroxidizable, but it's not exactly olive oil is not exactly magical or anything like that. It's better than a seed oil. So if you replace all all your seed oil consumption with olive oil, yeah, that's definitely a huge improvement, but it's not like it's optimal or anything like that, right? ah Consuming more linoleic acid increases the amount of linoleic acid in complicated aortic plaques.
00:33:30
chrisyzen
linoleic acid in adipose tissue and platelets positively associates with ah coronary artery disease whereas EPA and DHA in platelets are inversely correlated with coronary artery disease. Linoleic acid serum concentrations as opposed to per cent of fatty acids are higher in patients with coronary artery disease. ah God, it's long. Linoleic acid is inflammatory to the vascular endothelium.
Testing and Research on Omega-6 Impacts
00:34:04
chrisyzen
Linoleic acid metabolites promote cardiac arrhythmias, cell death, organ failure and cardiac arrest.
00:34:17
chrisyzen
Patients who have died from sudden cardiac death have more linoleic acid and less omega-3 polyunsaturated fats in their coronary arteries versus control patients who died mostly from traffic accidents. Now just to kind of talk about the omega-3 side of things, probably why they're correlating low omega 3s with all these conditions is because the omega 3s are so easy to peroxidize damage and kind of destroy that because usually the person that has the health problem has a lot of imbalances and stuff going on oxidative stress inflammation and stuff like that so
00:35:03
chrisyzen
that's been rampant for usually years and even decades and during that time these omega-3s have a a chance of getting peroxidized because again they're more they're even more vulnerable to this process they're even more fragile than omega-6s so The point being that it's not that having low omega 3s indicates caused those health issues, it's that
00:35:38
chrisyzen
those health issues caused low omega 3s because they got damaged and and they were no longer you know um measurable in the way that when you you know you but the thing is though if if they measured peroxidation byproducts of omega 3s as well as omega 3 levels they were probably likely to find them um so that when you're told yeah you need to take omega 3s for good It's good for your heart health and whatever else. it's If you already have a lot of this lipid peroxidation process, which again, of I've said it before, we can test for. We can check the fatty acids in the with a dried blood spot test conveniently collected at home. And then with the urine tested, we do the metabolomics. We can check for lipid peroxidation and other signs of oxidative stress. And that can really tell us how far down this
00:36:38
chrisyzen
quote-unquote, inflammatory oxidative stress state is a person and how much support and how how strict do they have to be with the stress reduction lifestyle, toxin cleanup, all the stuff, the nutritional supplementation support.
00:36:56
chrisyzen
Obviously, the further down the inflammatory and oxidative stress pathway a person is, the more that is required to ameliorate, mitigate, and resolve those issues and bring them back towards more closer to optimal health. So it's always good to have the data to know what you're working with. And then there was a few more points here, but at this point, even I'm kind of boring myself, so I don't really I don't really think it's worth um going. This is a very long paper. It's actually not that long, but they have quite a lot of a lot of studies ah in there. So if you if you were to start chasing down each one of them, it would it would turn into quite a quite um decent bit of research. um But I think it's very evident that
00:37:50
chrisyzen
At least to me, because i've I've kind of been looking at this for a while now, it's very evident that the less of these polyunsaturated fats that we have in our body, the more resilient our skin, our brain cells, our heart, our organs, and our blood vessels will be to inflammation per oxidative stress, oxidative stress damage in general.
00:38:18
chrisyzen
but Because the more of these you have in your body, these Omega-6s, the more vulnerable you are to damage. And the fact that it takes so long for these to get cleared out of the body means that the health longevity this is not I'm gonna do a two week detox and that that's me good now for the next year this is a lifestyle if you want to live a life free of disease or if you if you have a health issue that you want to resolve as much as possible if you want to live a long life as well on top of that so you you want to live not just disease free but quite a long time
00:39:07
chrisyzen
these are non-negotiables and just to be clear what the non-negotiables are it's a non-negotiable to reduce omega-6 ideally all polyunsaturated fat consumption it's a non-negotiable so if you feel like that's gonna be um ah what's the word I'm looking for it's gonna be a blocker so ah yeah but I like to go I like to have Kentucky Fried Chicken once a week but it's nice though it tastes though so if that's if that's a point of contention for a person then
00:39:47
chrisyzen
you know,
Mechanisms of Omega-6 Fats in Health Issues
00:39:48
chrisyzen
we can't help them. that that That's a decision they've made. And there's no point in kind of, you can do stuff to to ameliorate someone that's damaged and stuff like that. But if a person won't change basic habits, like what foods they eat, what, they what they order out when they're out, what processed foods they issue, if a person doesn't make those choices, like an adult should be able to,
00:40:17
chrisyzen
then they're screwed with a capital F, unfortunately, because these peroxidation byproducts, malondialdehyde and 4-HNE, 4-hydroxenol, these things are carcinogenic directly.
00:40:37
chrisyzen
so
00:40:41
chrisyzen
they're they we we We see the evidence that they're implicated in heart disease of its various shapes shapes and forms and whatever, coronary artery disease, atherosclerosis, stroke. So that's one thing. They're super immunosuppressive. They are polyunsaturated fats.
00:41:02
chrisyzen
They're associated with cancer. They're breakdown products which they spontaneously oxidize peroxidizing the body just by virtue that you're a warm-blooded mammal. Those breakdown products are directly either carcinogenic, toxic to the cells, mutagenic, damaged DNA, whatever else.
00:41:25
chrisyzen
so So even just the mechanistic sort of evidence, never mind all the other research that has been accumulating, even though the mainstream sort of narrative ignores that because they are bought and paid for by industry interests. um But even just understanding the mechanisms,
00:41:47
chrisyzen
which is very easy to understand at a high level. You don't have to be like a doctor or PhD to understand these things breakdown. Those breakdown products are toxic to ourselves. They damage things around them. It's not, it's not hard to understand. And once you know that, once you know which foods have a lot of omega sixes, which is anything that's ah that was a seed, a nut,
00:42:15
chrisyzen
ah or an oil or product made with those foods is going to have these omega omega-6s especially so it's not hard to understand okay so anything that was a seed likely had some or a lot of these omega-6s that includes you know nuts and a bunch of other stuff ah so what what's what's kind of the very simple logical deduction here well probably I don't want to eat too many of those foods that are high in omega-6s because those fats will become part of me, which means wherever they are lodged, with that cell or tissue or whatever,
00:42:58
chrisyzen
will then become more vulnerable to damage and then when i go out in the sun or i eat some something that have that has toxins in it or breathe something that has toxins in it like in traffic or whatever or i'm um just Again, just i I'm alone alive, mammal, 36 point whatever degrees ah Celsius, 98.6 Fahrenheit, that uses oxygen to make energy in itself. So oxygen, heat and light, especially the UV light, damage these things these things, these oils, these Omega 6 oils.
00:43:40
chrisyzen
day again I know I'm kind of repeating myself from certain previous episodes but it's it has to be people have to be reminded many times to kind of really truly grasp this message if these oils will go rancid in the fridge at five degrees Celsius and you're seven times or so warmer than that how much are they going rancid whilst in your tissues a lot because even the healthiest human being that you will find and you measure their lipid peroxides in the blood or urine or whatever where you're measuring them
00:44:24
chrisyzen
it's going to
Lifestyle Changes for Longevity and Health
00:44:25
chrisyzen
have some level of lipid peroxidation, right? So that's even the healthiest people have that. So this is why I think the some of these kind of biohackers that are that don't they want to live forever and stuff, I think it's a little bit
00:44:49
chrisyzen
far out, far fetched that of ah but um a mammal or or a human can live forever is because we create these reactive oxygen species and and there's always a little bit per oxidation even under optimal conditions. like even Just by virtue virtue of creating energy, even if we do it very cleanly and nicely, there's still some amount of this getting created, these reactive ah oxygen species and stuff like that. So I think it completely stalling aging is probably impossible.
00:45:30
chrisyzen
But if we know what we now know now already, I think we can do so much to to really, to if if you have a lot of Omega-6s in your body, yes, it will take time to get them out. But once you get them out safely,
00:45:47
chrisyzen
then there there's definitely things we can do to not halt but really slow down as much as possible the the damaging process to these to whatever is left in your body in terms of uh whatever omega sixes are are left because at the end of the day all foods contain them all foods contain them so you you'll never completely get rid of them The key is to to minimize them. For example, um most of my clients, when we run the um fatty acid analysis test, at least ah the omega quant one, because the metabolomics test
00:46:27
chrisyzen
that ah They also offer that as an add-on, but the I'm noticing somewhat of a difference between the two. But the Omega Quant one, which is ah kind of the most famous one, ah that one, when clients do that one, usually, if they've not been doing this low-pollin, saturated fatty acid sort of lifestyle, they would be between 37% and 40% Omega-6s.
00:46:57
chrisyzen
and to contrast that I've done that test twice and the first time I did it I was like 11% so compared 40% to 11% and then and I did it another time I was closer to 19% which I was kind of not happy about that my arachidonic acid was a bit high so i'm trying I'm trying to figure out why the second time it was double but it's still very much i was way lower than the bottom of the range of the test so that is possible and it's not even it's not even that hard it's just consistency that is how you get to a very low level in the blood and then the that by virtue of that
00:47:45
chrisyzen
but by virtue of having these ah low amounts of omega-6s and omega-3s, you have less substrate with which to make inflammatory molecules. So your inflammation potential is lower. Then you have less of these in your tissue, so less in In other words, you have more monounsaturated, more saturated fats in your tissues. So those are a lot more resilient to reactive oxygen species or other sort of byproducts that can be toxic to them or that that can damage them. So you are at the same time, there's less possibility for inflammation, so less damage, less oxidative stress. Then if there is inflammation,
00:48:25
chrisyzen
your tissues are more resilient because there's less of these vulnerable, susceptible, fragile ah Omega-6s and Omega-3s. So you become a much more resilient organism,
00:48:43
chrisyzen
right? So yeah, I could just, I could yammer on about this for another hour. I think I'll stop here, take a breather and start recording the next episode. So thanks for tuning in and I'll see you on the next one.