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Longevity vs. Anti-Aging - What Are We Doing?
90 Plays1 year ago
Do you need help with your health? Would you like to increase your longevity while addressing existing health issues?
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Check out the first volume in the How to Actually Live Longer series on Amazon: https://amzn.to/4dDXjxc
The Live Longer Formula is your go-to podcast for cutting through the noise and discovering practical, science-backed strategies to not just add years to your life, but to add life to your years. Hosted by longevity author and functional health practitioner Christian Yordanov, this podcast dives deep into the truths (and myths) behind longevity, health optimization, and addressing chronic health problems.
Each episode offers actionable insights drawn from the host's own research, clinical practice, and personal journey, helping you make informed decisions to restore and enhance your health. Whether you're interested in reducing stress, boosting your energy and mental performance, improving your gut health, or simply looking to optimize your diet and lifestyle, this podcast delivers the tools you need to live a healthier, longer life.
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Transcript
Introduction to Anti-Aging: A Client's Inquiry
00:00:45
chrisyzen
Hi, Christian Jordonov here. So one of my clients was asking me, what's my take on this anti-aging stuff? And is it real? Can we actually reverse aging and stuff like that? So I thought I'd record my thoughts on here so that you may also benefit from my thoughts if you find it, of course, informative.
Longevity vs. Anti-Aging: Concepts Compared
00:01:08
chrisyzen
So here's my take on it. So just let let's delineate between, first of all, what's longevity practices and what are anti-aging practices? So the longevity stuff,
00:01:18
chrisyzen
That is primarily concerned with what we do day to day, right? So maintaining good health. and maintaining function into our older ears and for many people nowadays that entails first reversing some of this dysfunction right so that's longevity so it focuses on diet stress management sleeping well right keeping stress as low as possible that's key um and then on the other hand anti-aging this will be more like
00:01:57
chrisyzen
I suppose ideally stopping or really slowing down the deterioration of body functions as we age and in in some cases reversing that deterioration of ah bodily functions right so slightly different one is protecting against it i suppose that's more longevity side of things then anti-aging would be like stopping it or reversing those processes if possible
Reversing Aging: Beliefs and Strategies
00:02:29
chrisyzen
And my take on it is that, of course, obviously, longevity practices and strategies. That's what we do on a daily basis. That's what I teach my clients. But I truly believe that we can achieve anti-aging type benefits with... I had to sneeze there. I truly believe we can reverse aging. And here's why, right? so
Aging as a Disease: Scientific Perspectives
00:03:00
chrisyzen
the A lot of my work with clients has been helping people restore their health and in order to restore your health, right so that means you're having some type of health problem whether diagnosed or not, in order to restore your health you need to repair damage, reverse these pathological processes and so on and so forth, right? So a lot of researchers nowadays are basically equating aging
00:03:36
chrisyzen
with disease because when you think about it, when you actually examine the the mechanisms, the processes that are that um ah create disease in the body, they're actually very similar or exactly the same as the processes that age us prematurely. Simple examples would be inflammation, chronic inflammation, stuff like that.
00:03:59
chrisyzen
ah unmitigated oxidative stress that's another one right so when you look at diseases conditions that there's an element of chronically elevated stress hormones like cortisol for example or serotonin um ah in in ah some kind of inflammatory in response some kind of immune system dysregulation is often a feature some kind of unmitigated ah aspect of oxidative stress which kind of goes hand in hand with inflammation,
Diagnostic Tests for Aging Processes
00:04:33
chrisyzen
right? So if a person can restore their health from such a problem, health problem,
00:04:43
chrisyzen
that means that they reversed or repaired or kind of stopped some of those pathological processes. So what that actually means is that, let's let's pretend the person doesn't have a health an overt health condition, but they're, let's say, in at the more advanced stage, and they've accumulated a lot of damage over the years, as you know most of us will have damage accumulation over the years.
00:05:10
chrisyzen
if you were to take that person and with a cup even with a couple of lab tests we can already identify a lot of things that are out of balance let's say so too much inflammation too much lipid peroxidation where you're you're like your lipids are getting damaged, right or lipid peroxidation, so they're getting damaged. which and Remember those lipids are part of mitochondria or cells or brain cells or heart cells or vascular system cells, so your ah blood vessels, organs. right So if those cells are getting damaged, we can measure that
00:05:50
chrisyzen
in in in um In in the the urine, for example, right there's a lipid peroxidation marker on one of the tests I run. We can also see if there's DNA damage, which is indicative of oxidative stress. So there's another marker, 8-OH-DG.
00:06:07
chrisyzen
8-hydroxy 2-deoxyguanosine, we can test for that on the metabolomics test, which is a urine collection, or the Dutch hormone panel, that's the advanced hormone panel that also
Addressing Inflammation and Nutrient Deficiencies
00:06:20
chrisyzen
includes it. So there's quite a few different tests, so we can test for inflammatory molecules in blood as well.
00:06:27
chrisyzen
So we can identify if these processes that accelerate aging and contribute to disease, we can identify in a particular person which of these are running rampant, which of these are unmitigated. And along with that, we can check whether they have um indications that there's nutrient deficiencies at play. For example, when a and and I don't just mean like blood like measuring blood levels because that's a very, um it's not exactly a very ah accurate way of measuring metabolically speaking if if there's a you know not enough of a nutrient because
00:07:12
chrisyzen
the blood level may be buffered to this very sort of tight physiological range at the expense of the tissues so certain more advanced tests like the metabolomics organic acids type tests with a urine collection you do at home we can see if there's a build-up of certain compounds in the urine, like organic acids, and when those are, for example, elevated, when there's a build-up of them, right, it's because a certain enzyme along a certain pathway could be an energy production pathway, for example,
00:07:48
chrisyzen
ah because that enzyme has that cofactor which could be a B a b vitamin or a mineral for example, ah it can't do its job because the cofactor is missing and that's why that compound can build up in the blood. We always have to take it with a grain of salt, sometimes it could be an absolutely different reason, right? So that's why I like to run a couple of tests at least, we and if we can correlate them with blood work,
00:08:10
chrisyzen
um Sometimes clients run, you know, $1,500, $1,800 worth of tests. We do like four or five tests and that really gives us a very good overall picture of it in terms of what is causing inflammation in the
Diet and Stress Management for DNA Protection
00:08:24
chrisyzen
body. It could be foods.
00:08:25
chrisyzen
It could be toxicity, it could be inflammation, because of perhaps there's a very high level of omega-6 fats in the body, right? There's so many different aspects that we can um uncover. And once we have this picture, we can then work to restore function or rather unblock those pathways, whatever the case may be.
00:08:53
chrisyzen
And what happens then is you you can lower DNA damage, you can lower oxidative stress, right? You can lower yeah not just the inflammatory potential and inside a person but how much how much of those inflammatory molecules are actually being created so we can actually Inhibit those from being from being created while the inflammatory potential of a person gets improved, which takes can take time if the case if we're talking about a very high seed oil consumption over the years. um That takes years and years to get out of the body, those Omega-6s, right? so But when we do this,
00:09:31
chrisyzen
And we start lowering things like stress hormones, cortisol and so on, pro-fibrotic hormones like ah serotonin. um And we start addressing immune or rather when we start addressing vitamin and mineral deficiencies or subclinical deficiencies. When we start doing that, the body gets more energy nutrients.
00:09:57
chrisyzen
And we start removing things that were detrimental, which could be exposure to toxins or an inability to detoxify well.
Cellular Repair and Nutrient Management
00:10:07
chrisyzen
When we start doing that, the body naturally starts to repair things, right? At the cellular level, which translates to the tissue level, that translates to the organ level. That means that the organs are functioning better. That means that that that organ system in the body will function better. That could be the cardiovascular, the digestive system, um you know whatever, right? And then that means that the organism
00:10:37
chrisyzen
will function better or its longevity will be increased. And this is how I believe we can actually and achieve anti-aging, quote unquote, ah type benefits in a person. So the longevity things is what we do on a daily basis, eating clean. Right. That's super important. If you don't do that, it's but it's just more likely that you will accumulate damage over time.
00:11:06
chrisyzen
as opposed to give you the best chance to start repairing accumulated damage. right So it's ah it's one or the other. You're either accumulating damage or you're repairing the ah ah damage that you've accumulated over the years.
Balancing Hormones for Youthfulness
00:11:21
chrisyzen
um So the other the other aspect of it is if we can restore the hormonal milieu inside a person where it more resembles the the hormone balance when they were saying their late teens or maybe early 20s, almost invariably in those folks, in those younger in that younger version of that same person,
00:11:49
chrisyzen
Usually you have higher levels of the protective hormone so they're still being created synthesized well and they're allowing and that allows for the stress hormones the catabolic or the the disease promoting hormones to be counterbalanced so that's what things like cortisol, progesterone, DHEA, pregnenolone, these balance or prevent the stress hormones like cortisol, adrenaline, serotonin, estrogen, they prevent them from running rampant in the body and causing disease and premature aging.
00:12:32
chrisyzen
So there's a few different ways we can do that. And again, we don't need to, I think it's a massive sort of misnomer or people are massively misled to believe that the only way to achieve a hormone profile of a younger person is to go to the HRT clinic and either for a woman get like esesttro some type of estrogen progesterone, progestin combination.
Supplements vs. Hormone Replacement Therapy
00:12:59
chrisyzen
And for a a man just getting TRT, testosterone replacement therapy, not only are those more expensive and sometimes more cumbersome in the case of testosterone, ah you have to inject it.
00:13:14
chrisyzen
But also what you would get but what a lot of doctors are recommending um prescribing in terms of these hormone HRT for women, you're getting an estrogen, some kind of estrogenic compound, which is straight up harmful. You shouldn't like no person should ever get extra estrogen in them. Right. So the public and most doctors are badly misled that estrogen is really ah what needs to be replaced in those situations.
00:13:44
chrisyzen
And then instead of a bioentical ah bioidentical progesterone, they're given a lot of women are given a synthetic proest progestin, right? And it's actually well known that some of those have estrogenic activity. So it's a really horrible, horrible thing. In fact, I had one client, once we started decongesting her liver, um she told me that suddenly like she was feeling horrible.
00:14:10
chrisyzen
And for whatever reason, she decided to stop taking her HRT that the doctor the her integrated physician had um prescribed, which was, she was taking a couple of other things, but the the one in question was, um an estro estrogen and and progesterone right that that that was the thing and she felt horrible and she stopped taking it and she said and I asked her how did that how did you feel after that she said I felt absolutely normal without the stuff so if that goes to show you what once we
00:14:48
chrisyzen
do the the you know stuff that we do with our clients. um Once you start restoring function to the body's organs and systems, you don't need these exogenous things to to function or to feel right. In fact, they can actually hinder that process. So um but the the way so the way I kind of approach this,
Restoring Youth Hormones with Supplements
00:15:10
chrisyzen
restoring hormonal levels of um these youth hormones is there's over-the-counter supplements that we can use right so anybody can get the stuff themselves and it's it's about so with with men it's about restricting testosterone or these androgenic hormones that are aromatizable into estrogen we want to restrict that process, right? Then we also want to give precursors to the androgenic hormones, like obviously testosterone, but also DHT because once once testosterone is turned into DHT, or rather one once is the final pathway in this um androgenic hormone or sort of ah set of pathways,
00:16:04
chrisyzen
DHT cannot be turned into estrogen, so it's non-arromatizable. So this is ah this is a big problem if you just go on TRT, get the testosterone injection. For a lot of men, that can cause a lot of estrogen to get created and from that testosterone, right? So that's definitely not good. And for women, what we want to do is especially the older woman gets after around menopause, the she's not producing levels of progesterone like back in the day. right so But she the the the the thing is that we continue to produce estrogen all our life. because we So women have the E2, the estradiol that's produced in the ovaries primarily. But you still have the E1 or the estrone that you continue to produce. right So um we men as well.
00:16:58
chrisyzen
So we want to restrict that as much as possible, right?
Managing Estrogen in Aging Women
00:17:05
chrisyzen
Because it it can run rampant way too easily in today's world because a lot of people are overweight and fat cells can't produce estrogen that you want because they have that aromatase enzyme.
00:17:17
chrisyzen
So we really want to be restricting estrogen from being created in both sexes and especially in men we want to be very careful not to boost testosterone too much, not to give too much of of substances that can be turned into estrogen. right So we want to restrict that process and then with women we want to support the progesterone sort of pathways. right and again these things we can do with cheap over-the-counter stuff like all of this i really believe all of this stuff some of these anti-aging clinics are doing with the the uh estrogen for women with some other bs progestin progestin not non-bioidentical progesterone the TRT
00:18:03
chrisyzen
A lot of these things are way overpriced or growth hormone, this kind of nonsense, injecting growth hormone is so crazyly overpriced, right? And it's not even beneficial. um So the crazy part is that people are wasting thousands on these things where yeah we we can get similar or even better results in fact much better results safer as well ah with over-the-counter supplements right so this is i believe we can achieve anti-aging benefits
00:18:39
chrisyzen
in in In other words, we can reverse aging with simple ah inexpensive over-the-counter supplements. right ah ah
Stress, Hormonal Balance, and Immune Function
00:18:51
chrisyzen
Here's another example. right so We know that stress and cortisol um They they atrophy the timer's gland which has plays a massive role in the immune system That's why people that are chronically stressed. They're more susceptible to infections and stuff like that, right? so We can actually if we undo that Hormonal milieu right so if we can counter and oppose and lower cortisol with those hormones of youth the protective hormones the
00:19:26
chrisyzen
Thymos gland can actually regenerate, right? There are certain of supplements that are thymotrophic, traffic I think is the word, not tropic, tropic. So that then that what that means is yeah you are restoring your immune system to to levels or to activity levels in a capacity where it was when you were younger.
Functional vs. Cosmetic Anti-Aging
00:19:52
chrisyzen
So these are the so when I say anti-aging,
00:19:55
chrisyzen
yeah People think anti-aging like very sort of in a cosmetic sense. And I do believe some of these some of these strategies that I use, they do have an effect in terms of reversing visible signs of aging, right? But to me, what's more important is can we restore the function of our organs to when we were, let's say, 30 or even 20? Because when you're 50 or 60, for example, or older,
00:20:24
chrisyzen
What's happening over time is you're accumulating damage that is being um in perfectly or sub-optimally repaired. And the reasons for that is it could be an overwhelming amount of toxic exposures, right, because of the environment, the plastics,
00:20:49
chrisyzen
um the air pollution, just what have you, name anything, you know, water that you shower with, that has toxins in it you know people that don't have really good ways to filter their water drinking from plastic bottles just not buying non-organic food just a million different ways almost literally of getting toxic insults On top of that, most people don't eat sufficient quantities of all the vitamins and minerals. but right So most people don't even meet their RDAs for all of their vitamins and minerals. And even if they did, that that's just to keep you alive. It's got nothing to do with optimal health. So you have suboptimal nutrition over a lifetime.
00:21:38
chrisyzen
with increasing toxic burden over a lifetime that causes damage to
Impact of Poor Nutrition and Toxic Exposure
00:21:43
chrisyzen
the body. So because the body triages nutrients and energy for the first for the most vital for survival function, so you have your brain, central nervous system, then you know you have your heart, lungs, kidneys, all this kind of stuff. And then if there's something left after that,
00:22:03
chrisyzen
it will go around, it will be kind of thinly spread, right? So because of that, because of these kind of influences, over time we accumulate, you could say pathological changes or or this damage in our tissues and organs. And that can be fibrosis. It can be, um,
00:22:30
chrisyzen
calcification in some places It can be ah in the skin. For example in in organs. It could be lipophuskin Lipophusin this age pigment and you can see it on the skin, but if you see it on the skin, it's in the organs We know that you can even go on the Wikipedia article and see for yourself. That's ah well known now so these are the sort of pathological changes that occur in our cells tissues and organs over time because of again imperfect nutrition coupled with chronic toxic exposure and a lot of stress and that shifts the hormonal milieu towards the catabolic stress side of things
Hormonal Balance: Critique of Low-Carb Diets
00:23:12
chrisyzen
um And it just puts you in a more of a degenerative state as opposed to regenerative, because these protective hormones like progesterone, testosterone, DHEA, pregnenolone, they ah stimulate you know protein synthesis, repair, regeneration, stuff like that, whereas cortisol, adrenaline, they they um they cause more degenerative types of so cortisol signals to our cells to break down, it holds the expression of like a ah new new proteins, right? So it holds those processes because it's an emergency type hormone, right? So this this is the scenario that we can, I believe we can actually start to to reverse if we add adequate nutrition,
00:24:05
chrisyzen
From the diet and supplementation, you I don't believe you can do this just with diet. And then we can we can start to oppose the stress hormone. So we've given the building blocks adequate energy, super important, right? So we need to actually, this is why low low carb diets are very, very bad for longevity because the body with a small amount of glucose coming exogenously, it will have to to be forced to make more of its own, and it will have to make do with a suboptimal amount less than is needed for all of the functions, right? This is where it starts to shut down non-vital forced survival functions. And then, so if we can
Consistency in Longevity Practices
00:24:45
chrisyzen
stop those things in their tracks and then add those precursors for those protective hormones, right? And make sure that it happens in a way where they don't get, due to stress or whatever other factors that are not up to the body, they don't get turned into like the estrogens or whatever else.
00:25:04
chrisyzen
then beautiful things can happen as long as you maintain this. You need to maintain it, you need to be diligent, you need to stay away from toxins as much as possible, do your cleanses, support your gut, all of the good stuff that I teach my clients, and ah sleep well, keep stress low, all of those things. If you do that, the body starts to repair right and this if If this is what it takes to reverse a chronic health problem or to restore health, where where it was visibly suboptimal or visibly in a bad state, it also means that we are reversing
00:25:43
chrisyzen
the aging process now we might not necessarily see it visibly if we're just doing this for like a month or two because remember this a lot of this damage takes years and decades to accumulate and you know it you can expect to reverse it in a month or two or even a year right because we're most people will not even do this perfectly so you're always kind of working at a somewhat of a deficit So you have to really dial everything in for this to like work well, and you have to maintain it. and But this, I believe, is how you can actually get those anti-aging benefits, where we chronologically, obviously, we cannot reverse aging, because that's a ah factor of time, right a function of time. But biological aging,
00:26:38
chrisyzen
can be reversed if we give the body what it needs to repair the damage that that we have accumulated over time right and that damage remember again it's a call the what are the causes of that damage what are the biggest as I call in in the how to actually live longer first volume um series I call them the the primary drivers of aging and dysfunction, and they are stress, inflammation, and oxidative stress. right And the byproduct of those things ah running rampant for years and decades is then more sort of ah physical changes in the body. So again, this fibrosis, which can turn into cancer over a long enough timeline,
00:27:26
chrisyzen
um ah Calcification of tissues, right? The formation of these various H pigments. So a lot of structural changes that what you see once is once a ah cell structure is damaged, its function is impaired. But its function ah its function being impaired can and will lead to its structure two to become impaired because it uses energy, the cell uses energy to maintain its structure. It's not like a house, you build the house once and the house will stay like that. With a cell, if a cell is like an analogy for a house, it's constantly making energy to do its functions, i to make proteins and whatever it the case may be.
00:28:19
chrisyzen
But some of that energy will go towards maintaining and repairing its structure. So if it's not getting sufficient energy nutrients, it something will suffer. It might be the function, it might be the structure, there's a trade-off that will have to be made, but eventually it will start to ah function sub-optimally. So our goal is to restore function to the cells by giving it what it needs and removing the toxic factors and this is where this is where the longevity practices are super important because how you can do all of the the cool advanced supplementation stuff that we do with my clients but if you're constantly being exposed to a lot of toxins, if you don't clean up your diet and eat only organic food, if you
Lifestyle Choices and Longevity
00:29:03
chrisyzen
If you're eating a lot of polyunsaturated fats, then your whole structure of your body is going to be more susceptible to damage. So then that will increase the demand and the burden on you to keep preparing. And it's very easy to to kind of lose control of that if you don't stay on top of these things really well, right?
00:29:24
chrisyzen
So I think bottom line, let me just see how long I'm recording here. Okay. 28 minutes is perfect. So I think bottom line, it's possible to do the anti-aging thing very um easily from the comfort of your own home without crazy operations and and and surgeries and and stem cells and stuff.
00:29:45
chrisyzen
You got to have your longevity stuff dialed in. So the long term choices, everything you make on a daily basis that has to be conducive to longevity. So if you really like going out to to restaurants a lot, well, that's that's something that is not conducive to longevity because you should go to a cash and carry and see what is being sold and what those people are buying to stock up the kitchen of those cafes and restaurants. Right.
00:30:13
chrisyzen
so if you're buying a lot of processed prepared food ah take out food that decision is feeding into the longevity aspect which means that you are getting more toxins ah over time which over decades is is very significant which will cause more damage over time and deplete nutrients that are required to detoxify these toxins and therefore less will less less will be there to go around for maintaining your nice to have functions. right So it's these daily choices that we make like shower filters and reverse osmosis systems and air filters and not buying you know ah cosmetics from the grocery stores that are not organic. So all of these things will go into the longevity bucket
00:31:07
chrisyzen
on top of which the anti-aging stuff can happen, right?
Internal vs. Cosmetic Anti-Aging Strategies
00:31:12
chrisyzen
But once those things are dialed in, at that point, we can then work to reverse those pathological processes that that the body has accumulated and restoring the hormonal milieu to that where ah you were younger or ah approximating that more. And the way we do that is support the protective hormones, supporting those levels, and that by default will actually have an oppositional effect, or an opposing effect on the more harmful ah ones like um ah cortisol, adrenaline, serotonin, which we know can drive, fibrosis in organs, estrogen, which is also implicated in a lot of cancers and stuff like that. so
00:31:59
chrisyzen
If you dial in the longevity there on top of that we can really create this this sort of anti-aging program Where again, just the the way I see it. It's it's not so much about the cosmetic benefits you you probably will see some cosmetic benefits or at least the The cosmetic damage will be a lot less over time. But to me it's that's that comes secondary right because the most important thing is can we start restoring function and then doing those damaging processes inside our like our vascular system, um our liver, our kidneys. you know Inside where you can't see anything right from the outside, that's where this damage is going to um exhibit the the biggest sort of detrimental effect
00:32:49
chrisyzen
on how long you live and how quickly you start to kind of accumulate enough damage ah where it begins showing as visible symptoms and and dysfunction,
Managing Toxins and Nutrients for Longevity
00:32:59
chrisyzen
right? So this is the anti-aging aspect that I believe is is possible. And then of course, if you have the cash, you could always go and get these cosmetic type treatments that are ah that can reverse the visible signs of aging. But for me, the most important thing is to remember that the visible signs of aging are a product of our internal environment, right? The toxins, how well we we're detoxifying, do we have borderline or subclinical nutrient deficiencies? um Are we creating a very inflammatory and environment in our body because, you know, we haven't got our gut sorted out or we, um ah you know,
00:33:38
chrisyzen
are eating just the wrong foods. we We just have to have those nuts and seeds or whatever the hell else we like to eat. So if we dial that stuff in then the external stuff will manifest more slowly. So those signs of aging will manifest more slowly.
00:33:55
chrisyzen
But the but the most beautiful part and I'm sorry if I'm repeating
Invitation to Join Longevity Program
00:33:58
chrisyzen
myself here. The most beautiful part is that inside The body these pathological processes that drive aging and premature premature aging disease and premature death They're the ones that we're going to be kind of ah shifting in the opposite direction, right? That is the beautiful ah part that we can do and again with very We can uncover these imbalances with very economically in the ground, skin you know, if you compare it to like going to doing stem cells and whatever other nonsense. ah Some of these crazy ah biohackers are doing, some of it is quite crazy, like injecting growth hormone that costs you like $5,000 a month, stuff like that, it's insanity.
00:34:44
chrisyzen
um We can do this with relatively inexpensive lab testing to uncover the the imbalances and then simple over-the-counter supplements and dietary strategies and stress reduction strategies and cleanses and detoxes and stuff like that to start reversing that damage that we uncover or those kind of plugging in those leaks and those holes that we uncover with the lab testing. It's a beautiful thing.
00:35:07
chrisyzen
And ah if you are interested in it, in working with me to kind of work on this kind of stuff, ah you can check below. I am actually at the moment, I'm working on a longevity program that I will be launching very soon. And if you want to be a part of that, if you want to learn more about that, details will be down below.
00:35:30
chrisyzen
and who knows maybe maybe someday soon we'll be talking together and we'll be working together and you're gonna get some of these amazing insights that I've had the opportunity to glean after these years in these ah at this point tens of thousands of hours of digging into this stuff and it would be a pleasure to share them with you so thanks for listening or watching and I'll see you on the next episode