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Omega-3s & Fish Oil: Are They Shortening Your Life?
117 Plays1 year ago
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Transcript
Introduction and Topic Reveal
00:00:01
chrisyzen
Hey, Christian, you're not here. Welcome back to the podcast. Today, I'm going to talk to you a little bit about why I do not recommend the Omega three slash fish oil supplements to my clients. I don't take them myself. Don't give them to my family. And I stopped. I stopped that last year. And it took but it took me months to come to terms that
Omega-3 Supplements: Concerns and Skepticism
00:00:31
chrisyzen
I'm not gonna sugarcoat it that I was poisoning myself with the supplements and and my family as well. So it it took a long time to come to terms with it. That's why I don't expect you to come to terms with it after listening to me talk about it for 30 minutes or so. But
Understanding the Risks of Omega-3
00:00:59
chrisyzen
this is not medical advice okay this is financial advice don't waste your money on omega-3 supplements right don't do it doesn't it doesn't matter if they are in a phospholipid form, molecularly distilled blessed by a holy man it doesn't matter if they are refrigerated and you you keep them in the fridge and all that good stuff right because also it should say it doesn't even matter that they're they come with antioxidants and tocopheros in there to protect them because at the end of the day what's gonna happen is you're going to ingest these things and if they somehow don't get
00:01:46
chrisyzen
peroxidized and they become part of you right part of your tissues eventually that's the fate that they're going to ah encounter almost invariably because and here's what you have to understand We know that omega-6s are bad for for a multitude of reasons, but one of the reasons omega-6 polyunsaturated fatty acids are bad for us is because they're unsaturated, right? So there um they have those unsaturations, those double bonds,
00:02:23
chrisyzen
those are vulnerable to this peroxidation process, right? To oxidation. And that that process breaks little pieces of them. And those pieces are ah carcinogenic, mutagenic, cytotoxic, toxic to our cells. They're just damaging. So when when one polyunsaturated fatty acid is um damaged,
00:02:47
chrisyzen
that causes a chain reaction of peroxidation reactions, and that needs to be stopped by some kind of an antioxidant, be that vitamin E, C, or some kind of antioxidant enzyme. So that's why one of the reasons why omega-6s are not great for you, and I discuss more of the reasons in my book how to actually live longer. but Here's the thing and this one when I kind of copped on to this last year a Lot a lot more things made sense. So it's for if at first You understand this what I just explained that these are very they're very fragile these um Omega sixes, but then Okay, you get that but then you once you understand that Omega threes are even longer even more unsaturated They have more double bonds
00:03:42
chrisyzen
which makes them even more susceptible to this but peroxidation process. So the more of these you have in your tissues, in your body, in your eyes, in your organs, in your brain, in your but wherever they may be, you know in in your cell membranes or whatever, your vascular system, doesn't matter, the more of these you have, the more it's like
00:04:10
chrisyzen
the more It's like having um dynamite in in your tissues and you just need to spark to light it up, you know? So that's why I don't i don't ah go out of my way to add them to my diet in terms of like supplementation. It's not like i I'm avoiding all foods that contain omega-3s.
00:04:36
chrisyzen
It's very hard to avoid these long-term polyunsaturated fats in general or you know in all foods almost.
Challenges in Research and Information Gathering
00:04:45
chrisyzen
so i just the ah ah The last thing I would do is I would buy ah omega-3 fish oil. you know ah Cod liver oil, it's more of a whole food. It has different fatty acids and vitamins and stuff.
00:05:01
chrisyzen
but um
00:05:05
chrisyzen
it's very susceptible to peroxidation. And those per peroxidation products, if whether they happen in the bottle when you drink them or they happen in your body, it's it's it's damaging, it's harmful, it accelerates the aging process, right? So that's kind of the the preamble here, but what today I've been wrestling with chat GPT for a couple of hours this thing i would punch it in the face the problem is ah i would be punching my own monitor so that kind of doesn't make a lot of sense but what i did was i have a list of maybe 30 40 or more studies that did show this kind of stuff you know the damaging effects of uh polyunsaturated fats dietary omega 3s
00:05:55
chrisyzen
um How they increase lipid peroxidation oxidative stress and various markers for oxidative stress and lipid peroxidation like Melan dial the height t-bars, you know thio barbituric acid um Reaction Sub something sub it's been a very long day and um This Chad GPT so I fed those papers in it and I told it Give me a table with everything um you know, the not not everything with the the study title the synopsis of the study and a link to PubMed and I tried multiple times it and it kept giving me giving me fake links to
00:06:46
chrisyzen
to the pub make so i would click a link in it with like some random other pubman pubman article that had nothing to do with the you know polyunsaturated fatty acids promoting you know cytotoxic reactions or whatever other stuff and i kept asking it so i asked it ah the first time I asked it why did you give me fake links and it said I apologize for the confusion earlier the links I provided were placeholders as I was in the process of gathering information from multiple sources um but here's the thing for this what I just did was if you take the study title which is what I gave it if you put it into DuckDuckGo or Google
00:07:26
chrisyzen
It the study comes up PubMed or somewhat Springer or whatever and you can just very easily Get get that information yourself, right? So the fact that it wasn't able to do that seems like Something nefarious is going on right? So I told it It gave me another table with fake studies. I said, redo the table with correct links. here's an ah It said here's an updated table with the correct PubMed links and summaries. Again, it gave me the wrong information. So let me see what I asked it then. Hold on, it's a long table.
00:08:02
chrisyzen
Um, hold on more, more Jesus. Okay. So then I said, why are you lying again? It said at the end, it said the stable includes accurate links and summaries. I said, why are you lying again? And listen to this chat GPT response. I sincerely apologize for the mistakes and confusion caused by the previous responses. Let me correct this by providing, providing accurate PubMed links and correct summaries for the studies you requested. I will cross check the information you to ensure accuracies and so on and so forth.
00:08:34
chrisyzen
Then it said, I apologize for the earlier issues with providing accurate and verified links. I will go step by step to gather the information for PubMed. Again, it gave me the wrong links. Okay. It gave me PubMed links that were going to different studies. I tried again. It did not give me the the correct studies.
00:08:55
chrisyzen
I said, are you? You are still giving me wrong links. Why are you continuing to do this? It said again, I apologize for the repeated mistakes. Let's go through the process correctly this time. I'll retrieve accurate links from reliable sources for each study you listed. I will search directly for each reference and provide you with the correct yeah URLs. Please allow me a moment. It sincerely, apologized again. And again, it gave me the wrong links.
00:09:24
chrisyzen
and and you know normally it only gave me 20 studies, again with the wrong links, and it wouldn't give me the entire list. And then I said, no, they're not correct again. How are you retrieving these? Show me your process. So then it showed me the process. Identify the study, search on PubMed, cross verify the details, copy the correct link. You know, it gave me the process, but it still gave me wrong data. And this is not the first time it's given me wrong data. I did the same thing a couple of months ago on heart disease stats. It was giving me fake, randomly generated, um, numbers for the years. Right. So.
00:10:00
chrisyzen
I asked it more stuff. it It thanked me for my patience. It said I'll notify once I've compiled all the correct links. It will take some time. um I asked are you done. It said I have now compiled the correct links and again it gave me the wrong stuff okay so something nefarious is going on it's been programmed with a narrative that it wants to you know uphold so then what i did is i i went i got the links myself to all of these studies and i put them in a in a doc and i told it ah so gave it some instructions and
00:10:44
chrisyzen
then it gave me the, it started giving me the tables that I wanted finally. It took a little bit more, you know, uh, but here's the thing. So once I gave it the, once it finally actually processed the study links I gave it, right? So the study is showing increased oxidative stress and shorter lifespan in animals and in people increased markers of oxidative stress and a bunch of other kinds of things like ah epidemiological studies not finding um you know benefit in terms of mortality or reduced cardiovascular ah incidents like myocardial infarction and stuff like that I said after all of this I gave it those links and told it to process it and in capital letters I said based only on the studies you just processed write several paragraphs summarizing the findings separated by topic
00:11:41
chrisyzen
And this this this just, I am livid here. If I wasn't exhausted, wrangling with it all day, i would I would be a lot lividder.
00:11:58
chrisyzen
so it started on So I asked it only on the studies that have shown negative effects. Give me summaries based on topics. So it started talking about cardiovascular health and omega-3.
00:12:10
chrisyzen
fatty acid. They said they've been extensively studied for their beneficial cardiovascular effect. um Several studies suggest that higher intake of omega-3s is associated with reduced risk of cardiovascular events, including heart disease and stroke. um Then it gives me some meta-analyses. Then mental health and omega-3 fatty acids. ah That the the systematic review meta-analysis supported the efficacy of omega-3 supplementation as an adjunctive treatment for depression.
00:12:40
chrisyzen
um that aligns with the findings of these other researchers than inflammation and autoimmune diseases. um omega So these are things, cognitive function and
Critical Analysis of Omega-3 Effects
00:12:51
chrisyzen
neuroprotection, metabolic health and omega-3 fatty acids. And it gave me a summary saying collectively these studies provide compelling evidence for the multifaceted benefits of omega-3 fatty acids across various domains of health from cardiovascular protection and mental health improvements to anti-inflammatory effects and neuroprotection. Omega-3's emerges crucial nutrients for maintaining health and preventing disease. Continuity blah blah blah. So then I, in capital letters I shouted at it, use only the studies I included in the list above. It gave me the same bollocks I had, I just clicked stop.
00:13:29
chrisyzen
so finally i'm like okay let's try a different angle here because the sun bitch is just gonna keep doing it will it will out loop me i can't keep asking the same thing because it it does not need to sleep and stuff like that so i'm like this is gonna take all day
00:13:47
chrisyzen
so i So I asked it, using the studies I provided you, explain the mechanisms via which omega-3s are harmful. So here now, this little bastard, it finally started giving me information that I wanted to relay to you. And this is what, here's the thing.
00:14:10
chrisyzen
It doesn't matter if you're not a biochemist or a physiologist or a doctor whatever epidemilogologist or epidemiologist or epidemiologist. It doesn't matter if you're not those things. yeah If you can understand simple mechanisms in terms of how the body works, right, that can be enough information to make a decision as to whether something, an intervention or a supplement of or a food is beneficial or not. So this is what i tried to this is why I know there's a lot of guys out there that have covered all this Omega 3 is harmful research.
00:14:52
chrisyzen
in much greater depth and have calmed over everything you know very um granularly. But my my goal is to just give ah person a regular person out there ah a basic understanding of the stuff why it's not good so that they don't get hoodwinked by all the mainstream news, um mainstream health press articles about how it's good, how everybody's singing Omega 3's praises.
00:15:24
chrisyzen
and even all these studies they could have a they could find a negative finding but the abstract of the study could frame it still as a positive finding or as uh neutral even though there's clearly a negative finding right so here's chat gpt finally actually giving us some mechanisms via which and I apologize for the long sort of prelude to this but I was just just to explain to you why are so why are people so confused why is this information not making it out there because the algorithms are preventing it very hard if they're making it extremely difficult to get this information and they're getting increasingly more more sophisticated because we're training the damn thing anyway
00:16:18
chrisyzen
So the studies provided indicate several mechanisms. through which omega-3 fatty acids can potentially be harmful under certain conditions. And again, it's always like, um potentially under certain conditions, normally they're great, but if something like, ugh, you know, ugh. So, oxidative stress and lipid peroxidation. One of the primary concerns with omega-3 fatty acids, particularly when consumed in high amounts, is their susceptibility to oxidation.
00:16:53
chrisyzen
There's a study there, Song et al, 2013, discussed how omega-3 fatty acids, due to their polyunsaturated nature, are prone to lipid peroxidation. This process generates reactive oxygen species, which can cause oxidative stress and damage cellular components like proteins, DNA, and lipids. Keep in mind,
00:17:18
chrisyzen
these cellular components could be in a cell in the brain, in your heart, in your liver, in your vascular system, your you know your arteries, whatever. So it could be your skin, right? So things you need to function well, right? So the more oxidative stress and damage to these cellular components, the more damage to the cell, the quicker that cell will become dysfunctional the quicker the tissue will become dysfunctional and then the organ and then the organ system and then the organism you so the more of this happens oxidative stress and cellular damage the faster we age the faster we develop disease okay now oxidative stress is linked to various diseases including cardiovascular disease and cancer
00:18:12
chrisyzen
as these damaged molecules can disrupt normal cellular functions and promote infl inflammatory responses. Then omega-3s can be pro-inflammatory they have pro-inflammatory effect in certain contexts. Again, with all of these sort of qualifiers, it's absolutely exhausting um dealing with this nonsense. While omega 3s are generally known for, and again, it's again more qualifiers, whilst it's generally known that they have anti-inflammatory properties, some studies suggest that under certain conditions, they might contribute to inflammation.
00:18:47
chrisyzen
Lee et al. in 1997, accessible through PubMed, indicates that in the presence of high oxidative stress or when improperly metabolized, omega-3 fatty acids can form pro-inflammatory compounds. These compounds can exacerbate inflammatory processes rather than mitigate them, particularly in individuals with compromised antioxidant defenses. If you grab a copy of my book, How to Actually Live Longer, um in chapter three I talk about um the antioxidant status of the average American, how poor it is. And this is, again, so in certain contexts, they're pro-inflammatory. If you look at the average American or the average person in terms of their diet, their stress levels, you know their nutrient status, how much oxidative stress and inflammation is going on in their body, this is most, not most, but the majority of people
00:19:47
chrisyzen
out there are already, they already in their body have this environment that predisposes to these um super fragile omega-3s to be peroxidized, right? So,
00:20:08
chrisyzen
you know, telling me that they can be they can in certain, you know, high oxidative stress states, they can be improperly metabolized to to these pro inflammatory compounds. You know, many, many people, I think more than 50% of the population already have this higher than, you know, should be oxidative stress, right? So these certain contexts are freakin common.
00:20:35
chrisyzen
So I wouldn't use this qualifier, you know, but obviously it's it's completely biased, right? Another thing here. So remember anti-inflammatory means so inflammation is mediated by the immune system. And this is the the one that actually floored me last year. And I kind of understood this a little bit better. And that's when I really.
00:20:54
chrisyzen
double down on getting these things out of our diet and by the way I mean my family we we weren't like eating Omega taking Omega 3 pills and stuff for the most part it was cod liver oil ah Maybe in the five bottles we went through in the last five five years six years so not that much and we would we eat fish because we live by the ocean and we would um I would ah feed my wife and my daughter cod liver from the can with the oil and I'll give that to my dog and ah fish eggs or hake roll as it's called very delicious my kid loved it and And I would open up a little can of that and, ah you know, split it up two, three times a week between all of us. So we're getting a little bit, maybe a gram or two of Omega 3s each time. So not not a huge amount by any means. And there's a lot of other other nutrients there, protein, um um
00:21:57
chrisyzen
minerals and whatever else so it wasn't like it was a whole food it wasn't all that bad right but here's the thing the reason omega-3s and just polyunsaturated fats in general are anti tea-inflammatory quote-unquote is because they are immunosuppressive they suppress the immune system so of course
00:22:24
chrisyzen
Chad GPT is walking on eggshells and it's like potential negative impact on immune function. Another concern is the potential immunosuppressive effects of high-dose omega-3 supplementation. ah Brown et al. 2012, published in Journal of Clinical Epidology, discusses how accessible omega-3 intake can alter immune cell function. This alteration can lead to reduced resistance to infections, impaired wound healing.
00:22:54
chrisyzen
yeah as omega-3s may dampen the body's inflammatory response, which is crucial for fighting infections and repairing tissue damage. um It didn't really mention the the the stuff about the cancer metastasis in rats.
00:23:11
chrisyzen
That study somehow got, it missed that study where the omega-3s were promoting a tenfold increase in tumor metastasis.
Historical Context and Health Implications
00:23:26
chrisyzen
that That study was in there. I know it because I put it in there this morning.
00:23:31
chrisyzen
ah So fun fact. back in like the 70s they used to use plug and saturated fats they would give the oils to when a person would get their an organ transplant so ah the old organ transplantee transplantee to stop their immune system, their body from rejecting the organ, they would give them these omega-3s and various body and saturated fatty acids ah oils to to suppress their immune system. So they're immunosuppressive. And if you suppress the immune system sufficiently and for long enough, that is very conducive to cancer proliferation. And this is where you have to a little bit put on your tinfoil hat because
00:24:19
chrisyzen
this There's a lot of money already in the fish oil industry, billions and billions, but and it takes a long time. like In the short term, this immunosuppressive effect, it will suppress you certain um inflammation markers. So if you do a study for a month, two months, three months, which is often all that's done with a lot of these type of studies, interventions,
00:24:48
chrisyzen
you will get a good effect and then you can build a large body of evidence on these short-term studies that will then oh my god skyrocket this thing into prominence. everybody's using it every Even in my textbook of natural medicine,
00:25:02
chrisyzen
the chapter on on Omega-3's fissure oil is huge, tons of studies in there, um ah standard conventional doctors are using it, so everybody is using it. And this is something that I've realized over my years, studying the stuff is as soon as something is a little bit more mainstream.
00:25:22
chrisyzen
you have to sort of raise an eyebrow and and start thinking, that whoa, whoa, whoa, something, something. I smell a rat. I smell a rat, you know? So we have to really question everything. And again, this
00:25:38
chrisyzen
this does not manifest quickly. So you could take this fish oil for years and years and years, decades, and then maybe one day if you have a health issue, how are you ever going to pinpoint that on the fish oil on this gradual, um but constant lipid peroxidation, depletion of antioxidants. And by the way,
00:26:00
chrisyzen
We can test for this um with my clients. When we run the metabolomics test, which which is a urine collection, um we can see lipid peroxides as a marker. And we can also do an add-on test, which only costs like 50 bucks, um that checks for or fatty acids in in the blood. It's a dried blood spot test you collect on a piece of card. So you you ship that back to the lab, they pick that up, a courier picks it up from your home, ah super convenient. And we then can see the lipid peroxides and we can see the state of the rest of the fatty acid, right? And I've noticed the pattern when the lipid peroxides are in the yellow, right? So not in the green, green is lowish, low to lowish.
00:26:51
chrisyzen
and then yellow is obviously medium and then red is bad but yeah to me yellow is not freaking good either i wouldn't want to ever to be in the yellow or any of my clients to be in the yellow but in the yellow means there's an increase in lipid peroxidation the pattern i've noticed is then the um omega 3s will be like low in the red and the the lab's automated report will recommend a thousand two thousand milligrams of um Omega 3's and I'm like I tell my clients you know just please for the love of God ignore the auto-generated report no it's not all bad of course it's it's interesting for clients to read about and you know educate themselves about this stuff but that particular aspect of it is again it's all based on literature and of course if all the literature is
00:27:47
chrisyzen
designed to to push the narrative, then what what are you going what do you expect? right it's got That's what evidence-based is nowadays. The problem is if you're evidence-based and evidence-limited, you are screwed or potentially your clients or if you're a doctor, your patients are screwed.
00:28:06
chrisyzen
because the evidence base can obviously and this is not the only example in many other examples can be really badly skewed can be a house of cards built on very sort of precarious footing so this immunosuppressive effect again long-term look at look at the rise in cancer Look at, do you think it's a coincidence that the increase in polyunsaturated fat consumption, omega-3s and 6s over the last hundred years or so, do you think it's a coincidence? So this makes a lot of money and then it it can feed the cancer industry. that's That's why I personally feel free to disagree, but that's why I think Chad GPT
Potential Harms and Health Monitoring
00:29:03
chrisyzen
has made it so damn hard today to actually extract ah some counter sort of position on the amazing effects of omega-3s. And there's more. you know There's increased bleeding risk. ah it this is It gave me that based on the studies I gave it. um
00:29:24
chrisyzen
yeah Potential diabetogenic effects. but there's a lot more that it didn't, right? And I'm gonna be doing more deep dives, but the what i what I was planning to do is in volume two of the How to Actually Live Longer series, I'm going to um have a whole chapter on this and kind of look look at it from a deeper level, all the different mechanisms. And again, look, they can give us a lot of different amazing research
00:29:56
chrisyzen
and all that all your it lowered your cholesterol it lowered your oh whatever right your inflammatory markers so first of all who cares about those cardiometabolic markers are just kindergarten stuff and then okay it lowered the inflammation but what what what about six twelve months down the line five years down the line right what about what happens then And then the again, the beauty of this ah lab testing that we can do with, we can order for clients, direct to their home, collected conveniently in the home and picked up by courier. We can actually see your level of lipid peroxides and DNA damage. There's a marker called 8-hydroxy 2-deoxyguanosine.
00:30:44
chrisyzen
it o h d g That's another marker that can indicate oxidative stress. So when these are, I mean, I've never seen them like in the red, but when we see them with clients on in the yellow, there's definitely a lot of room for improvement in terms of that person's biochemistry, physiology, antioxidant status, stuff like that. But here's the thing.
00:31:11
chrisyzen
We've seen this in clients that are not necessarily, they don't have a serious health issue. right They just came to me to optimize some stuff, get like you know do some lab testing, see what's up. So these people are already functioning at a high level. And in some cases taking eating really well, doing the low toxin lifestyle type thing. and um Taking tons of supplements, you a couple of dozen supplements, good quality stuff. But we we are seeing these markers in the yellow, so something is going on.
00:31:46
chrisyzen
in in the person in terms of inflammation, oxidative stress, some other stress that is causing this somewhat elevated lipid peroxidation. And again, you might feel good for a very long time before you see the the some kind of outward manifestation of these damaging processes. So the key is, this is why What we do with my longevity program is so powerful because why wait when why wait until you develop a symptom? Why wait 20 years? you Do you wait for your car to break down and then you go fix it? Most people don't do that. You you go to the mechanic once a year and they check it out. They're like, okay, this is going to wear out soon. Let's change that, but blah, blah, blah.
00:32:34
chrisyzen
so why shouldn't we do that with our vehicle the most important vehicle we'll ever own the only vehicle really that matters at the end of the day so this is the kind of stuff we find and then the the beauty is we can address these things with supplementation diet and certain lifestyle things. you know You don't have to do um don't have to do these ah gene therapy or crazy sort of ah stem cell stuff. No, no a lot of the stuff, most of the stuff we address with targeted supplementation, you have to know what you're doing. Dietary changes in some cases, and just basic stress reduction, but ah things like you know gut health,
00:33:17
chrisyzen
ah the improving detoxification, improving hormone balance, right? Because if you have a lot of Omega 3s or Omega 6s in your body, then any stressor becomes a spark to them, right? So getting dialing in the stress, lowering the stress is so important, especially because it takes years for these polyunsaturated fats to get out of your body to kind of be replaced with better ah quality ah building blocks. So during that time you want to keep stress inflammation and oxidative stress really low. Those are the three primary drivers of aging and dysfunction as I talk about in volume one of the how to actually live longer series. so
00:34:03
chrisyzen
Yeah. Excuse me. I will be doing further deep dives ah into this. It's, um, it's a bit of a rabbit hole. As you can see, it's difficult again to, it's difficult to undo conditioning like this, but trust me, if, if you think this is, you know, wow, or whatever, if you're a little bit sort of awestruck with this,
00:34:31
chrisyzen
I guarantee you there are dozens of other things that you could potentially be doing that could be doing your harm or or more harm than good. So the best way to get ahead of the game in this side of things is to work with me as a client.
Solutions and Optimizing Health
00:34:50
chrisyzen
So you can go to my website, link is down below, and you can apply for a free call with me or where we can discuss your health goals and see if we are fit to work together. I can explain how we can help you achieve your goals by enrolling you in my Live Longer Formula, which is the name of my health optimization and longevity program.
00:35:14
chrisyzen
and it's it's designed to address existing health issues because most people actually do have existing imbalances and health issues. nobody Almost nobody's coming like with an ideal state of health looking to optimize it further. Everybody, especially after the age of about 40, has a bunch of imbalances, some more than others, right? But the key is This is what I help clients to do is we quickly identify those and then we quickly begin addressing them comprehensively, right? And then over the course of us working together, you're going to learn everything you need to know to maintain your health for life. So that's kind of the goal of my program is to help you identify, address these, you know, imbalances and whatever else, and then
00:36:05
chrisyzen
teach you, give you the tools and help you install the habits and the practices that will then help you maintain your health for life. So you don't need to keep coming back to me. This model,
Conclusion and Call to Action
00:36:17
chrisyzen
ah peel for a nail, come back when you you're a sicker.
00:36:20
chrisyzen
this This has to be replaced with something better when it's education and ah just a set of eyes that can really help you identify what to work on, what where what will move the needle for you the most. Then after that, you have the tools to continue on your journey.
00:36:42
chrisyzen
and you know continue maintaining your health well into old age. So if you're interested in that, you can check the link down below, go to the website, see what it's all about and you can then take the next step and apply for a free intro call with me. And then of course, if you if you qualify, we can we can talk and meet and see how how we can make beautiful things happen. So thanks for tuning into this episode and I will see you on the next one.