One thing we've realized after 10+ years as business owners is that it's actually harder to take a vacation as a business owner than it was as an employee. My current boss is WAY more challenging than my previous ones ever were. ;)
After a few vacations that involved way too much time in front of a computer dealing with tasks that "had to be done" at that moment, we've learned that when it comes to a vacation from your business, a little prep work goes a long way.