167. The Gut-Immune Axis | Gastrointestinal Mucus & Lactoferrin, Lactoferrin Levels, a Brief Discussion on Candida Overgrowth, & More
In this episode, we detail the gut-immune axis, focusing on the protective mucus layer, antimicrobial peptides, and the role of lactoferrin in intestinal health. We discuss endogenous secretions and how lactoferrin functions as an antimicrobial, immunomodulatory, and iron-regulating glycoprotein, influencing microbial balance and intestinal barrier integrity. Additionally, we highlight lactoferrin testing and levels. We finish by going through supplementation as a phenomenal tool.
Topics:
1. The Intestinal Barrier & Mucus Layer
- The intestinal lumen, microbiome, mucus layer, epithelial cells, and lamina propria.
- The mucus layer: antimicrobial peptides (AMPs) and secretory IgA (sIgA).
- Intestinal epithelial cells including goblet cells and enterocytes.
2. Immune Cells in the Gut
- The lamina propria.
- Macrophages, dendritic cells, neutrophils, B cells, T cells, mast cells, and more.
3. Antimicrobial Peptides & Secretory IgA
- AMPs and sIgA in the mucus layer regulate microbial balance and prevent pathogen adhesion.
4. Lactoferrin: Functions & Sources
- Iron-binding glycoprotein, antimicrobial and immunomodulatory properties.
- Found in mucosal secretions, colostrum, and more.
- Intestinal epithelial cells (IECs) and neutrophils.
5. Lactoferrin’s Role in Intestinal Health
- Regulates iron absorption via lactoferrin receptors (LFR)on enterocytes.
- Sequesters free iron, limiting bacterial growth, bacteriostatic.
- Destabilizes bacterial membranes, cell lysis, bactericidal.
6. Lactoferrin Levels
- Neutrophils release lactoferrin during infection,increasing its presence in the large intestine.
- Fecal lactoferrin levels.
- Fecal calprotectin levels.
7. Lactoferrin & Candida Overgrowth
- Fungal membranes.
- Aiding in the inhibition of biofilm formation.
8. Lactoferrin Supplementation & Benefits
- Supports gut microbiota, epithelial integrity, and immunemodulation.
- Bovine colostrum and as a supplement.
9. Conclusion
- The intestinal mucus layer is key to gut barrier function.
- Lactoferrin plays a central role in microbial regulationand immune defense.
Thank you to our episode sponsors:
1. Shop Fresh Press Farms'Peach Cider Vinegar at Sprouts locations nationwide, and check out their full collection here.
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