157. Intestinal Mucus & Its Role in Protecting The Epithelium & Supporting The Intestinal Barrier, Interactions Between The HPA Axis & Microbiome, The MTHFR Gene & Methylation | 3 Top Topics from 2024

This episode explores three top topics from episodes in 2024: the mucus layer's protective role in maintaining gut barrier integrity, the bidirectional relationship between the microbiota-gut-brain axis and the hypothalamic-pituitary-adrenal (HPA) axis, and the importance of methylation and the MTHFR gene. During the first topic of discussion, we detail ways to support the intestinal mucus layer; as we approach the third topic of discussion, we highlight the impact of MTHFR enzyme activity on methylation, emphasizing its importance for many cellular processes.

Topics:

• 1. Introduction: 3 Top Topics of 2024

• 2. The Protective Mucus Layer Over the Intestinal Epithelial Lining

  • The intestinal barrier: intestinal lumen, microbiome, mucus layer, epithelial cells, lamina propria, and more.
  • The mucus layer functions as both a physical and biochemical barrier.
  • Goblet cells secrete mucins, which form the gel-like mucus layer, critical for maintaining barrier integrity.
  • Dysregulation of mucus turnover can lead to increased intestinal permeability and inflammation.
  • Supporting mucus levels: SCFAs, N-acetylglucosamine (NAG).
  • Plant-derived mucilage and sources.

• 3. HPA Axis and Microbiota-Gut-Brain Interactions

  • The HPA axis and the stress response.
  • Microbiota-gut-brain axis.
  • SCFAs produced by gut bacteria can influence gut barrier integrity and stress resilience.
  • Dysbiosis disrupts SCFA production, weakens the gut barrier, and triggers inflammation.
  • Dysbiosis and HPA axis dysregulation.
  • Chronic cortisol secretion and secretory IgA.

• 4. The MTHFR Gene and Methylation

  • Methylation involves transferring methyl groups.
  • The synthesis of SAMe, the universal methyl donor: methionine and ATP with active folate (L-methylfolate) as a precursor.
  • MTHFR gene polymorphisms reduce enzyme efficiency, impairing methylation and affecting DNA stability, neurotransmitter synthesis, and detoxification.
  • Strategies, supplements, and more to support methylation.

Thank you to our episode sponsor:

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