#275 Why "Normal" Bloodwork Misses Years of Aging Cellular Drift & Multi-Omics Testing | Dr. Adrijana Kekic @futurome

Your annual physical came back "normal," so why do you still feel foggy, tired, and stuck? Dr. Adrijana Kekic says your biology has probably been drifting for years before any standard test notices.

Former Mayo Clinic pharmacogenomics specialist and Futurome founder Dr. Adrijana Kekic reveals what a standard 30 to 100 marker panel misses, how multi-omics testing catches metabolic drift early, and why women age differently after 40. After a preventable pulmonary embolism nearly killed her, she rebuilt her own health and now maps cellular aging for people who look fine on paper.

Meet our guest

Dr. Adrijana Kekic is a pharmacist and nutritionist trained in genetics, one of the first pharmacogenomics clinical specialists at Mayo Clinic and winner of its 2023 Innovation Award. She founded Futurome, a precision health intelligence company that reads thousands of biomarkers to map cellular aging, with a special focus on female biology.

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Key takeaways

• Standard panels lean on late markers; fasting insulin and HOMA-IR flag metabolic trouble years earlier.
• Multi-omics testing reads thousands of markers across genomics, proteomics, metabolomics, and microbiome.
• Cellular aging spikes around 40 and 60, the windows where personalization pays off most.
• The highest mitochondrial density in women sits in the ovaries; decline can surface there before any blood test.
• Perimenopause is estrogen swinging up and down, not just falling; it hides on standard labs.
• Women make about 50% less gut serotonin than men, so fasting protocols should differ by sex.
• Foundation first: sleep, magnesium, vitamin D, movement, and a CGM before advanced interventions.

Episode highlights

0:00 Normal labs, hidden aging

6:09 What standard bloodwork misses

18:24 The two aging cliffs at 40 & 60

25:33 The perimenopause you don't notice

30:27 The ICU wake-up call

40:40 Foundation before shiny objects

46:18 Why men & women differ

Links

• Watch it on YouTube: https://youtu.be/1P-vuKmzvtw 
• Full episode show notes: https://outliyr.com/275

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