In this encore episode, we highlight vitamin D₃ in gastrointestinal health, with a focus on intestinal barrier function and the gut-immune axis. We discuss how vitamin D is metabolized into its active form, 1,25-dihydroxyvitamin D, and how 1,25-dihydroxyvitamin D can support intestinal health, while highlighting intestinal mucosal anatomy.
Topics:
1. Introduction
- Highlighting intestinal barrier function and the gut-immune axis with a focus on vitamin D₃
2. Vitamin D Synthesis and Metabolism
- Skin and 7-dehydrocholesterol; dietary intake.
- Transported through the bloodstream bound to vitamin D binding protein.
- First hydroxylation in the liver to form 25-hydroxyvitamin D₃ (25(OH)D₃).
- Testing.
- Second hydroxylation in the kidney to form the active 1,25 dihydroxyvitamin D₃ (1,25(OH)₂D₃).
- Local activation also occurs.
3. Intestinal Barrier Anatomy
- The intestinal epithelium forms a selectively permeable monolayer that interfaces with the gut lumen.
- Covered by a mucus layer.
- Tight junction proteins and paracellular permeability.
- The lamina propria and Gut-Associated Lymphoid Tissue (GALT).
- Maintaining tolerance.
4. Vitamin D
- 1,25-dihydroxyvitamin D₃, tight junction integrity, immune regulation, and more.
5. Vitamin D₂ and D₃
6. Conclusion - Neither too high nor too low: optimal levels.
- Multifactorial: Numerous factors regulate vitamin D levels.
- Gastrointestinal health root cause approach.
Thank you to our episode sponsor:
1. "Longevity" with Protein, Probiotics, Bovine Colostrum, Collagen, and More. Use code CHLOE for 25% off.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
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