December 1 is World AIDS Day, and January 2023 marks 20 years of the President’s Emergency Plan for AIDS Relief (PEPFAR), which provides for groundbreaking AIDS treatment, prevention, and research. In this episode of Big World, SIS dean Shannon Hader, an expert in infectious diseases and epidemiology and a global leader in the fight against HIV/AIDS, joins us to explore how the AIDS response informed policies during the outbreak of COVID-19 and how politics impacts the public perception of public health crises. Dean Hader discusses how PEPFAR’s monumental achievements have influenced public health policy (3:22) and how PEPFAR continues to garner bipartisan, bicameral support from Congress, even throughout a time of intense political division (5:43). She explains how blame and shame are not sustainable or effective responses to an infectious disease (11:30). She also talks about the dangers of putting the goals of disease prevention and treatment in opposition to one another (13:23). How did the HIV community respond to the emergence of the COVID-19 virus (17:07)? While with UNAIDS, how did Hader help advise public health officials on how to protect human rights amid a crisis (18:51)? Hader answers these questions and discusses the importance of data in making sound decisions and targeting resources (21:01). The episode concludes as Hader shares how her impressive career in public health prepared her to lead a top-10 international relations school (27:17) and what she hopes to accomplish while at SIS (31:20). During our “Take Five” segment, Hader shares the five steps she would recommend to governments around the world to create and sustain positive forward momentum on AIDS research, prevention, and treatment (22:29).