In this episode of Skin Anarchy, Dr. Ekta Yadav sits down with longtime friend and beauty industry force Jaimee Holmes for an intimate conversation that marks a new chapter in her career—the launch of Fel. Known for shaping some of the most iconic products in prestige beauty, Holmes opens up about the personal experiences, creative pauses, and emotional clarity that ultimately led her to build something entirely her own.

The episode traces Jaimee’s journey from her early days at Sephora—where she learned the power of founder vision and retail storytelling—to pivotal roles at Benefit, Perricone MD, and Too Faced. She reflects on leading the launch of Better Than Sex Mascara, the conviction it took to push past skepticism, and how trusting instinct over trend can redefine an entire category. Later chapters at Kendo and Goop offered a different lens: overseeing countless brands and SKUs revealed just how crowded—and emotionally disconnected—the industry had become.

That realization, paired with personal loss and reflection, became the quiet catalyst for Fel. Rather than chasing what’s next, Holmes chose to look inward—building a brand rooted in nostalgia, emotion, and the universal language of a kiss. Fel’s debut, Kissylips, is designed to be felt as much as worn: playful, tactile, and intentionally uncomplicated, with packaging and textures that evoke memory rather than perfection.

At its core, Fel is about responsibility and care—especially for younger consumers. From globally clean, vegan formulations to a proprietary fel-good complex™ designed to support both the lip barrier and emotional wellbeing, every detail is deliberate. This isn’t makeup built for speed or spectacle—it’s built for connection.

Listen to the full episode of Skin Anarchy to hear Jaimee Holmes share how Fel came to life, why meaning matters more than momentum, and how beauty’s future may be rooted in feeling something again.

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Creating Iconic Products and Intentional Beauty with Jaimee Holmes of Fel Beauty

In this episode of Skin Anarchy, Dr. Ekta Yadav is joined by Dr. Steven Dayan, Dr. Sabrina Fabi, and Dr. Nathan LeBrasseur—key advisory voices behind AMWC Americas—for an inside look at why this meeting has become one of the most influential platforms shaping modern aesthetic medicine.

As an official media partner, Skin Anarchy and Dr. Ekta are part of the global conversations unfolding at AMWC Americas—conversations that go far beyond injectables to explore longevity science, systems-based care, and how real-world clinical insight travels across borders. What makes this meeting different, the guests explain, is its truly international lens. 

From early-career clinicians to seasoned experts, the meeting prioritizes anatomy, physiology, and safety—most notably through its standing-room-only live cadaver dissection sessions. For many providers, this hands-on anatomical education is both rare and transformative, refining technique and elevating patient outcomes.

A central theme throughout the conversation is the convergence of aesthetics and longevity. Rather than focusing solely on correction, AMWC Americas increasingly addresses hormones, peptides, nutrition, inflammation, and metabolic health—recognizing that durable aesthetic results depend on biological resilience, not isolated procedures.

Listen in to hear why AMWC Americas isn’t just a conference—it’s a benchmark for where the field is headed.

Attend AMWC Americas

Register for AMWC Americas [https://www.amwcamericas.com/en/aesthetic-medicine-conference-miami-2026/Pricing-pass-options.html]: use code EKTA for 20% off registration

At AMWC, make sure to join the incredible presentations scheduled by Dr. Nathan LeBrasseur, Dr. Steven Dayan, Dr. Sabrina Fabi, and Dr. Ekta Yadav!

Dr. Nathan LeBrasseur:

Welcome Keynote Address: Aging: Can We Intervene? A Longevity-Informed Approach for Aesthetic Practice | Saturday, February 14 | 9:00am - 10:00am ET

Aging: Can We Intervene? A Longevity-Informed Approach for Aesthetic Practice | Saturday, February 14 | 9:05am - 9:50am ET

Dr. Steven Dayan:

Welcome Keynote Address: Aging: Can We Intervene? A Longevity-Informed Approach for Aesthetic Practice | Saturday, February 14 | 9:00am - 10:00am ET

Full-Face Anatomy Review on Cadaver for Injectors (includes Ultrasound Imaging) | Saturday, February 14 | 2:00pm - 3:30pm ET

Lunch & Learn: Beyond Treating Lips and Cheeks, Patients Desire Facial Balancing - Featuring Live Injections with the Galderma Portfolio*Live Demonstration Sponsored By: Galderma | Sunday, February 15 | 12:15pm - 1:15pm ET

Dr. Sabrina Fabi:

Sponsored Lunch & Learn: Perimenopausal Skin: Clinical Considerations Sponsored By: Allergan Aesthetics | Saturday, February 14 | 12:30pm - 1:30pm ET

Lunch & Learn: Beyond Treating Lips and Cheeks, Patients Desire Facial Balancing - Featuring Live Injections with the Galderma Portfolio*Live Demonstration Sponsored By: Galderma | Sunday, February 15 | 12:15pm - 1:15pm ET

Dr. Ekta Yadav: 

When Skin Speaks: Understanding the Mind-Skin Connection | Saturday, February 14 | 1:00pm - 2:15pm ET

Perception, Identity, and Aesthetic Decision-Making: Understanding the Patient Mindset | Saturday, February 14 | 1:20pm - 1:35pm ET

Breaking Boundaries: Revolutionary Approaches to Clinical Skincare & Peels | Saturday, February 14 | 3:30pm - 4:45pm ET

The Longevity Gap: How Post-Treatment Skincare Protects Aesthetic Outcomes | Saturday, February 14 | 4:20pm - 4:35pm ET

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The Global Future of Aesthetic Medicine with AMWC Americas Leaders Ft. Dr. Steven Dayan, Dr. Sabrina Fabi, & Dr. Nathan LeBrasseur

In this Masterclass episode of Skin Anarchy, Dr. Ekta Yadav welcomes back Dr. Barbara Paldus of Codex Labs for a compelling deep dive into integrative dermatology—a next-generation approach that treats skin not as a surface problem, but as a window into whole-body health.

This conversation reframes chronic skin issues through a systems lens, exploring how the gut, brain, immune system, hormones, and microbiomes continuously communicate—and how disruptions in one system can ripple outward to the skin. Instead of asking “How do we suppress this flare?” Dr. Paldus challenges us to ask “Why is the skin signaling distress in the first place?”

You’ll hear how stress, inflammation, microbiome imbalance, and intestinal permeability can quietly drive conditions like acne, eczema, rosacea, and psoriasis—often long before symptoms appear on the skin. The episode unpacks why conventional symptom-focused treatments sometimes fail to deliver lasting relief, and how root-cause care can create more durable, meaningful outcomes.

Dr. Paldus also introduces a personalized teledermatology model that leverages biological data, at-home testing, and longitudinal tracking to design interventions tailored to each patient’s unique internal landscape. From hormone-driven breakouts to chronic eczema and immune dysregulation, the discussion highlights how precision diagnostics can guide smarter, more sustainable treatment strategies.

At its core, this episode invites listeners to rethink skincare entirely—not as a cycle of stronger products or short-term fixes, but as a long-term investment in systemic resilience.

If you’re curious about the future of dermatology, microbiome science, and why healing skin often starts far beyond the mirror, this episode offers a powerful preview of what root-cause, science-led care can look like.

Listen to the full episode to explore how integrative dermatology is reshaping chronic skin care from the inside out.

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*This is a sponsored collaboration

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Masterclass Monday: The New Era of Personalized Skin Science at Codex with Dr. Barbara Paldus

In the third installment of the Skin Anarchy and Timeline Masterclass, Dr. Ekta Yadav sits down with Dr. Brad Currier, Manager of Clinical Trials at Timeline, for a behind-the-scenes look at what real evidence in longevity science and skincare actually requires.

With a foundation in muscle physiology, exercise science, and aging research, Dr. Currier brings a performance-driven lens to longevity — reframing skin not as a cosmetic surface, but as a mitochondria-dense longevity organ, biologically linked to muscle health, metabolic resilience, and cellular energy. The episode explores why mitochondrial function may be one of the most underappreciated drivers of how both skin and the body age.

At the center of the conversation is Timeline’s research on urolithin A, a postbiotic shown to support mitochondrial renewal. Rather than relying on marketing narratives, Timeline has built its platform on mechanism-first science, translating years of cellular research into human clinical trials — including biopsy-based studies that reveal measurable changes in collagen synthesis and skin structure.

Dr. Currier also pulls back the curtain on the truth about clinical claims in beauty — explaining why many “clinically tested” labels lack rigor, how underpowered or biased studies distort results, and what separates meaningful, published human data from perception-based marketing. From wrinkle depth to hydration to barrier function, he outlines how Timeline measures outcomes that reflect real biological change — not just surface-level improvement.

The episode ultimately reframes longevity as precision science, not hype — emphasizing the importance of human trials, mitochondrial health, and transparent evidence in an industry flooded with buzzwords.

Listen to the full episode of Skin Anarchy to hear Dr. Brad Currier unpack what clinical validation should look like — and why the future of longevity skincare depends on measurable biology, not marketing promises.

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Masterclass Monday: Understanding the Fundamentals of Clinical Trials in Skincare ft. Timeline and Dr. Brad Currier

In this episode of Skin Anarchy, Dr. Ekta Yadav sits down with Dr. Tiffany Libby for a clear, science-forward conversation on supplements, cellular energy, and why NAD biology has become such a focal point in modern longevity discussions. As interest in “aging better” grows, this episode cuts through hype to explore what NAD optimization can—and cannot—realistically do for skin and whole-body health.

Dr. Libby brings a rare perspective to the conversation. As a board-certified dermatologist and Director of Mohs Surgery at Brown University Health, her work spans both skin cancer care and cosmetic dermatology, treating patients across decades of life. That long view has shaped her understanding of longevity not as youth preservation, but as maintaining resilience, repair capacity, and function over time—especially in the face of inflammation, environmental stress, and chronic disease.

Much of the discussion centers on why supplements, particularly NAD boosters, are having a cultural moment. Dr. Libby explains that this surge reflects a gap in the healthcare system itself—one that prioritizes treatment over prevention. While supplements can offer support, she emphasizes they are not shortcuts. Longevity still rests on fundamentals: sleep, nutrition, movement, stress regulation, and inflammation control.

The episode offers a practical breakdown of NAD (nicotinamide adenine dinucleotide), explaining its role in mitochondrial energy production, DNA repair, and cellular defense. As NAD levels decline with age, skin becomes less efficient at repairing damage, producing collagen, and maintaining barrier integrity. Crucially, Dr. Libby explains why NAD itself can’t be absorbed directly—and why precursors like nicotinamide riboside (NR) matter instead.

Throughout the conversation, skepticism and safety remain central themes. In an underregulated supplement space, quality, dosing, and clinical validation matter. From a dermatologic standpoint, supporting mitochondrial health may help skin function closer to its biological potential—but only when paired with evidence-based care and realistic expectations.

Listen to the full episode of Skin Anarchy to hear Dr. Tiffany Libby unpack the science of NAD, cellular energy, and why longevity begins with supporting biology—not chasing promises.

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Lessons in Longevity: Debunking NAD and Cellular Health with Dr. Tiffany Libby of Niagen Bioscience

In this episode of Skin Anarchy, Dr. Ekta Yadav welcomes Carolina Reis Oliveira and Alessandra Zonari, co-founders of OneSkin, for a rigorous, eye-opening conversation that reframes skincare as a true longevity intervention. Part of the Lessons in Longevity series, this episode asks a bold question: what if skin aging isn’t cosmetic at all—but cellular, systemic, and deeply biological?

OneSkin began not as a brand, but as a lab-based mission. Trained in stem cell biology, tissue engineering, and genomics, Carolina and Alessandra spent years growing real human skin in the lab to test existing products. What they found challenged the industry: many so-called “anti-aging” formulas increased inflammation, cellular stress, and long-term damage. Meanwhile, longevity science was accelerating—yet skin, the body’s largest organ, was being left out of the conversation.

At the center of the episode is cellular senescence—a state where damaged cells stop dividing and begin secreting inflammatory signals that degrade surrounding tissue. In skin, this process weakens the barrier, disrupts collagen, and accelerates visible aging. Rather than masking symptoms, OneSkin set out to target this root cause. After screening hundreds of compounds, they developed OS-01, a proprietary peptide shown in lab models to significantly reduce senescent cell burden while increasing collagen—without irritation.

The conversation also expands beyond the face. OneSkin’s decision to focus on body skin revealed something unexpected: improving the skin barrier may reduce systemic inflammation. Clinical data discussed in the episode suggests that healthier skin doesn’t just look better—it may influence whole-body aging.

This episode is a must-listen for anyone curious about where skincare, biotech, and longevity science truly intersect.

Listen to the full episode of Skin Anarchy to hear how OneSkin is redefining skin as a living organ—and why the future of longevity may start at the surface.

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Lessons in Longevity: The Science Behind OneSkin with Co-Founders Carolina Reis Oliveira and Alessandra Zonari

In this Fragrance Friday episode of Skin Anarchy, Dr. Ekta sits down with Pissara Umavijani, founder and perfumer of Parfums Dusita, for a quietly powerful conversation about perfume as emotion, memory, and meaning. In an industry increasingly driven by trends and virality, Dusita stands apart as a house built on poetry, patience, and feeling.

Pissara shares her deeply personal journey—leaving Thailand to start over in Paris with a singular intention: to create fragrance that makes people feel. Entirely self-taught, she immersed herself in the craft of perfumery through persistence and intuition, guided by a belief that scent should communicate something human, not perform for attention. Even the name Dusita, which refers to a level of paradise in Thai culture, reflects this ethos—living with purpose, warmth, and emotional presence.

Rather than relying on obvious cultural motifs, Dusita expresses Thai heritage through values: gentleness, hospitality, compassion, and balance. These qualities shape not only the fragrances themselves, but how the brand engages with people—inviting closeness rather than spectacle.

At the heart of every Dusita fragrance is poetry written by Pissara’s late father. Each poem serves as an emotional blueprint, translated into scent rather than illustrated literally. This approach comes to life in beloved creations like Tonka Latte, a soft, comforting gourmand inspired by warmth and love, and Pavilion d’Or, a serene composition that captures balance and stillness without adhering to a single category.

Throughout the conversation, Pissara returns to one guiding principle: balance. For her, great perfumery isn’t about intensity—it’s about harmony, evolution, and restraint. Dusita’s fragrances don’t demand attention; they reward it.

Listen to the full Skin Anarchy episode to hear how poetry, Thai cultural values, and emotional honesty shape Parfums Dusita—and why the most powerful fragrances are often the quietest ones.

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Poetry, Balance, and the Art of Scent with Pissara Umavijani of Parfums Dusita

In this episode of Skin Anarchy, Dr. Ekta Yadav is joined by Dr. Yannis Alexandrides and Eva Alexandridis, the husband-and-wife team behind 111 Harley St. and 111SKIN, for a candid, science-forward conversation on regenerative aesthetics, protocol-based skincare, and what longevity really looks like when it’s rooted in medicine—not marketing.

111SKIN didn’t start as a beauty brand. It began in the operating room. Dr. Alexandrides shares how his work in facial plastic surgery led him to develop skincare that could support faster healing and stronger outcomes after surgery—when nothing on the market met his clinical standards. What surprised him most wasn’t just improved recovery, but the long-term transformation in skin quality patients experienced once healing was complete. That insight became the blueprint for translating surgical-grade science into daily care.

A central theme of the episode is maintenance. Procedures, Dr. Alexandrides explains, are only as successful as the skin’s baseline health. Eva expands on this philosophy, emphasizing that 111SKIN was never about instant fixes—it was about training skin to behave better over time. Longevity, in their view, is built through consistency, restraint, and respect for biology.

The conversation also dives into the brand’s measured approach to advanced technologies like exosomes—used as targeted protocols rather than trends—and the broader shift in aesthetics toward regeneration over replacement. From deep plane techniques to micrografting, Dr. Alexandrides explains why modern plastic surgery is moving away from excess and toward preservation.

Throughout the episode, one message remains clear: longevity aesthetics aren’t about changing who you are—they’re about supporting skin health so you can look like yourself, for longer.

Listen to the full episode of Skin Anarchy to hear Dr. Yannis Alexandrides and Eva Alexandridis unpack the science behind 111SKIN, regenerative skincare, and the future of evidence-based aesthetic care.

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Pioneering Protocol-Based Solutions for Skin Longevity Featuring 111SKIN Founders Dr. Yannis Alexandrides and Eva Alexandridis

In this episode of Skin Anarchy, Dr. Ekta sits down with Natasha Denona for a rare, reflective conversation that traces the creative and philosophical roots of one of modern makeup’s most influential brands. Known for palettes that have become industry benchmarks, Natasha opens up about how her work has always been driven less by trends—and more by intention, education, and respect for the user.


Growing up between science and art shaped everything. Natasha’s mother, a chemist in inorganic chemistry, exposed her early to laboratories, precision, and technical thinking. While chemistry itself didn’t immediately click, the discipline behind it did. That structured curiosity later resurfaced in how Natasha approaches formulation, texture, and product architecture—where creativity is always grounded in control.


Before makeup, there was painting, theater, and dance. Natasha shares how color became both emotional language and psychological tool, first explored through art and stage makeup. That foundation explains why her palettes feel cohesive yet expressive—each one designed as a complete story rather than a collection of random shades.


A defining theme of the episode is education. Natasha doesn’t create products to sit on a shelf; she designs tools that teach. Long before “educational beauty” became a marketing buzzword, her launches embedded technique—guiding users through layering, sculpting, and dimension the way professional artists actually work.


Rather than chasing novelty, Natasha deliberately builds for longevity. Palettes like Biba and Camel weren’t designed for a moment—they were designed to last across ages, skin tones, and styles. Inclusivity, she explains, has always been non-negotiable, not performative. Her decision to launch 52 foundation shades wasn’t strategic—it was personal.


Throughout the conversation, one belief remains constant: the product should be the star. Natasha never wanted her image to overshadow the work itself.


Listen to the full episode of Skin Anarchy to hear Natasha Denona reflect on creativity, inclusivity, and why true innovation in beauty comes from intention—not trends.


SHOP NATASHA DENONA [https://go.shopmy.us/p-37463450]


CHAPTERS:

(0:02) - Welcome & Introducing Natasha Denona

(1:14) - Growing Up Around Science, Art, and Photography

(4:43) - Early Relationship With Color, Makeup, and Expression

(6:11) - From Dance & Modeling to Makeup Artistry

(7:26) - Building Iconic Color Stories & Palette Philosophy

(9:05) - Inclusivity as a Core Creative Principle

(13:19) - Creating Complexion Products at Scale

(17:05) - Longevity, Creativity, and Avoiding Trends

(24:08) - Entrepreneurship, Visibility, and Authentic Leadership


Please fill out this survey [https://acast-d25653fd59cf.intercom-clicks.com/via/e?ob=Xwbs3fWtzyOKLv6rRENmXId6r2IPPa%2BoscPS5zgs2743j434Md3ri6%2B6Ur7nVVp7&h=2339d3f749f10e90f4a027c3950fc365bf7012f3-ayi0335i_215469449012753] to give us feedback on the show!


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Building a Beauty Brand Beyond Trends with Natasha Denona

In this episode of Skin Anarchy, Dr. Ekta sits down with Denise Vasi, founder and creative force behind MAED, for a thoughtful conversation about building beauty with intention, patience, and care. Denise’s path into the industry began early—signed to Ford Models and immersed in on-set artistry long before social media shaped beauty culture. Those formative years, paired with memories of her grandmother’s at-home esthetic rituals, planted the seed for a philosophy rooted in preparation, respect, and craft.


Before MAED ever existed, Denise built something rarer than hype: community. Through years of honest storytelling around wellness, motherhood, and clean living, she created a dialogue with women who trusted her voice. That trust shaped MAED’s slow, deliberate evolution. Rather than chasing trends or speed, Denise chose to listen—developing products only when they solved real, lived problems.


At the heart of the brand is a deceptively complex product: the red lip. Denise unpacks why most formulas fail—dryness, poor undertones, and exclusion baked into development—and how MAED set out to fix that. Comfort came first, followed by rigorous testing across skin tones, lip shapes, ages, and backgrounds. Inclusivity, she explains, isn’t a campaign—it’s formulation, design, and function.


Central to MAED’s ethos is one guiding principle: care before color. Lips lack oil glands and cannot repair themselves without real barrier support. MAED’s formulas focus on hydration, resilience, and wear—so color performs because the foundation is healthy.


Beyond product, the conversation explores beauty as ritual and self-expression. The red lip becomes more than pigment—it’s confidence, protection, and presence.

Listen to the full episode to hear Denise Vasi share the philosophy behind MAED, the science of lip health, and why meaningful beauty innovation starts with care—not trends.


SHOP MAED [https://shopmy.us/collections/3377746] and learn more on their social media [https://www.instagram.com/maedbeauty/]!


CHAPTERS:

(0:02) - Introduction & Welcoming Denise Vasi

(0:59) - Early Career: Modeling, Beauty Sets & Formative Influences

(2:16) - Building Community Through Editorial & Made.co

(4:48) - Slow Beauty, Brand Intention & Resisting Trend Cycles

(7:13) - Reimagining the Modern Red Lip

(8:04) - Formulation, Testing & True Inclusivity

(12:16) - What Inclusivity Really Means in Beauty

(16:30) - Lip Health, Barrier Science & Care-First Formulation

(23:10) - Care Before Color & The Cultural Power of a Red Lip


Please fill out this survey [https://acast-d25653fd59cf.intercom-clicks.com/via/e?ob=Xwbs3fWtzyOKLv6rRENmXId6r2IPPa%2BoscPS5zgs2743j434Md3ri6%2B6Ur7nVVp7&h=2339d3f749f10e90f4a027c3950fc365bf7012f3-ayi0335i_215469449012753] to give us feedback on the show!


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Redefining the Modern Red Lip with Denise Vasi, Founder of MAED

Join Ekta as she discusses skincare trends, social issues, and myths around skincare and beauty culture. Join the discussion on Instagram @skincareanarchy! (Not legal or medical advice, all views expressed are non-legal and non-medical opinions) Support this podcast: https://anchor.fm/skincareanarchy/support

Ekta Yadav

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